Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 5502950..5503545 Replicon chromosome
Accession NZ_AP027197
Organism Escherichia coli strain 02E060

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag QMG97_RS28130 Protein ID WP_000239579.1
Coordinates 5503195..5503545 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QMG97_RS28125 Protein ID WP_001223208.1
Coordinates 5502950..5503201 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG97_RS28115 (5498615) 5498615..5502394 + 3780 WP_000060926.1 autotransporter assembly complex protein TamB -
QMG97_RS28120 (5502397) 5502397..5502738 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QMG97_RS28125 (5502950) 5502950..5503201 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QMG97_RS28130 (5503195) 5503195..5503545 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
QMG97_RS28135 (5503625) 5503625..5504155 - 531 WP_000055075.1 inorganic diphosphatase -
QMG97_RS28140 (5504465) 5504465..5505421 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QMG97_RS28145 (5505561) 5505561..5507063 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
QMG97_RS28150 (5507077) 5507077..5508099 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T43467 WP_000239579.1 NZ_AP027197:5503195-5503545 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T43467 NZ_AP027197:5503195-5503545 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT43467 WP_001223208.1 NZ_AP027197:5502950-5503201 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT43467 NZ_AP027197:5502950-5503201 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References