Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2225711..2226237 | Replicon | chromosome |
| Accession | NZ_AP027197 | ||
| Organism | Escherichia coli strain 02E060 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | QMG97_RS11760 | Protein ID | WP_000323025.1 |
| Coordinates | 2225711..2225998 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | QMG97_RS11765 | Protein ID | WP_000534858.1 |
| Coordinates | 2225998..2226237 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMG97_RS11710 (2220735) | 2220735..2220950 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| QMG97_RS11715 (2221170) | 2221170..2221340 | + | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| QMG97_RS11720 (2221704) | 2221704..2221919 | - | 216 | WP_000066483.1 | cold shock-like protein CspB | - |
| QMG97_RS11725 (2222220) | 2222220..2222432 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| QMG97_RS11730 (2222487) | 2222487..2222576 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| QMG97_RS11735 (2222854) | 2222854..2223606 | - | 753 | WP_001047133.1 | antitermination protein | - |
| QMG97_RS11740 (2223620) | 2223620..2224669 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| QMG97_RS11745 (2224671) | 2224671..2224949 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| QMG97_RS11750 (2225016) | 2225016..2225267 | - | 252 | WP_000980994.1 | protein Rem | - |
| QMG97_RS11755 (2225484) | 2225484..2225639 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| QMG97_RS11760 (2225711) | 2225711..2225998 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| QMG97_RS11765 (2225998) | 2225998..2226237 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| QMG97_RS11770 (2226262) | 2226262..2226567 | + | 306 | WP_001326990.1 | protein YdfV | - |
| QMG97_RS11775 (2226770) | 2226770..2227102 | + | 333 | WP_001317460.1 | FlxA-like family protein | - |
| QMG97_RS11780 (2227539) | 2227539..2227688 | - | 150 | WP_180302674.1 | protein YdfW | - |
| QMG97_RS11785 (2227761) | 2227761..2228858 | - | 1098 | Protein_2310 | ISNCY family transposase | - |
| QMG97_RS11790 (2228913) | 2228913..2229332 | - | 420 | WP_001151195.1 | DUF977 family protein | - |
| QMG97_RS11795 (2229373) | 2229373..2230338 | - | 966 | WP_000054507.1 | hypothetical protein | - |
| QMG97_RS11800 (2230319) | 2230319..2230840 | - | 522 | WP_000705349.1 | toxin YdaT family protein | - |
| QMG97_RS11805 (2230824) | 2230824..2231051 | - | 228 | WP_000476993.1 | Cro/CI family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleC | 2135419..2240365 | 104946 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T43448 WP_000323025.1 NZ_AP027197:c2225998-2225711 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T43448 NZ_AP027197:c2225998-2225711 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT43448 WP_000534858.1 NZ_AP027197:c2226237-2225998 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT43448 NZ_AP027197:c2226237-2225998 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|