Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1178495..1178973 Replicon chromosome
Accession NZ_AP027197
Organism Escherichia coli strain 02E060

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag QMG97_RS05740 Protein ID WP_001303876.1
Coordinates 1178495..1178782 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag QMG97_RS05745 Protein ID WP_000536233.1
Coordinates 1178782..1178973 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG97_RS05710 (1173718) 1173718..1176168 - 2451 WP_000048583.1 exonuclease -
QMG97_RS05715 (1176262) 1176262..1176453 - 192 WP_001098307.1 DUF1482 family protein -
QMG97_RS05720 (1176450) 1176450..1176638 - 189 WP_000413705.1 cell division inhibition protein DicB -
QMG97_RS05725 (1177206) 1177206..1177415 + 210 WP_001133037.1 hypothetical protein -
QMG97_RS05730 (1177416) 1177416..1178054 - 639 WP_000394543.1 hypothetical protein -
QMG97_RS05735 (1178066) 1178066..1178218 - 153 WP_000380316.1 DUF1391 family protein -
QMG97_RS05740 (1178495) 1178495..1178782 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QMG97_RS05745 (1178782) 1178782..1178973 - 192 WP_000536233.1 hypothetical protein Antitoxin
QMG97_RS05750 (1179001) 1179001..1179402 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
QMG97_RS05755 (1179511) 1179511..1179783 + 273 WP_000887453.1 YdaS family helix-turn-helix protein -
QMG97_RS05760 (1179767) 1179767..1180192 + 426 WP_000693855.1 toxin YdaT family protein -
QMG97_RS05765 (1180399) 1180399..1180854 - 456 WP_000273724.1 hypothetical protein -
QMG97_RS05770 (1180933) 1180933..1182048 + 1116 WP_001205821.1 hypothetical protein -
QMG97_RS05775 (1182055) 1182055..1182801 + 747 WP_000788742.1 ATP-binding protein -
QMG97_RS05780 (1182823) 1182823..1183593 + 771 WP_000451007.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T43438 WP_001303876.1 NZ_AP027197:c1178782-1178495 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T43438 NZ_AP027197:c1178782-1178495 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT43438 WP_000536233.1 NZ_AP027197:c1178973-1178782 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT43438 NZ_AP027197:c1178973-1178782 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References