Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 1912380..1912906 | Replicon | chromosome |
| Accession | NZ_AP027191 | ||
| Organism | Escherichia coli strain 10153 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | QMG89_RS10340 | Protein ID | WP_000323025.1 |
| Coordinates | 1912619..1912906 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | QMG89_RS10335 | Protein ID | WP_000534858.1 |
| Coordinates | 1912380..1912619 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMG89_RS10295 (1907566) | 1907566..1907793 | + | 228 | WP_000476993.1 | Cro/CI family transcriptional regulator | - |
| QMG89_RS10300 (1907777) | 1907777..1908298 | + | 522 | WP_000705349.1 | toxin YdaT family protein | - |
| QMG89_RS10305 (1908279) | 1908279..1909244 | + | 966 | WP_000054507.1 | hypothetical protein | - |
| QMG89_RS10310 (1909285) | 1909285..1909704 | + | 420 | WP_001151195.1 | DUF977 family protein | - |
| QMG89_RS10315 (1909759) | 1909759..1910856 | + | 1098 | Protein_2014 | ISNCY family transposase | - |
| QMG89_RS10320 (1910929) | 1910929..1911078 | + | 150 | WP_180302674.1 | protein YdfW | - |
| QMG89_RS10325 (1911515) | 1911515..1911847 | - | 333 | WP_001317460.1 | FlxA-like family protein | - |
| QMG89_RS10330 (1912050) | 1912050..1912355 | - | 306 | WP_001326990.1 | protein YdfV | - |
| QMG89_RS10335 (1912380) | 1912380..1912619 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| QMG89_RS10340 (1912619) | 1912619..1912906 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| QMG89_RS10345 (1912978) | 1912978..1913133 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| QMG89_RS10350 (1913350) | 1913350..1913601 | + | 252 | WP_000980994.1 | protein Rem | - |
| QMG89_RS10355 (1913668) | 1913668..1913946 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| QMG89_RS10360 (1913948) | 1913948..1914997 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| QMG89_RS10365 (1915011) | 1915011..1915763 | + | 753 | WP_001047133.1 | antitermination protein | - |
| QMG89_RS10370 (1916041) | 1916041..1916130 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| QMG89_RS10375 (1916185) | 1916185..1916397 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| QMG89_RS10380 (1916698) | 1916698..1916913 | + | 216 | WP_000066483.1 | cold shock-like protein CspB | - |
| QMG89_RS10385 (1917277) | 1917277..1917447 | - | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| QMG89_RS10390 (1917667) | 1917667..1917882 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | galU / paa / nleA/espI / nleA/espI | 1848340..1949630 | 101290 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T43401 WP_000323025.1 NZ_AP027191:1912619-1912906 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T43401 NZ_AP027191:1912619-1912906 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT43401 WP_000534858.1 NZ_AP027191:1912380-1912619 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT43401 NZ_AP027191:1912380-1912619 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|