Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1214695..1215173 Replicon chromosome
Accession NZ_AP027191
Organism Escherichia coli strain 10153

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag QMG89_RS06020 Protein ID WP_001303876.1
Coordinates 1214695..1214982 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag QMG89_RS06025 Protein ID WP_000536233.1
Coordinates 1214982..1215173 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG89_RS05990 (1209918) 1209918..1212368 - 2451 WP_000048583.1 exonuclease -
QMG89_RS05995 (1212462) 1212462..1212653 - 192 WP_001098307.1 DUF1482 family protein -
QMG89_RS06000 (1212650) 1212650..1212838 - 189 WP_000413705.1 cell division inhibition protein DicB -
QMG89_RS06005 (1213406) 1213406..1213615 + 210 WP_001133037.1 hypothetical protein -
QMG89_RS06010 (1213616) 1213616..1214254 - 639 WP_000394543.1 hypothetical protein -
QMG89_RS06015 (1214266) 1214266..1214418 - 153 WP_000380316.1 DUF1391 family protein -
QMG89_RS06020 (1214695) 1214695..1214982 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QMG89_RS06025 (1214982) 1214982..1215173 - 192 WP_000536233.1 hypothetical protein Antitoxin
QMG89_RS06030 (1215201) 1215201..1215602 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
QMG89_RS06035 (1215711) 1215711..1215983 + 273 WP_000887453.1 YdaS family helix-turn-helix protein -
QMG89_RS06040 (1215967) 1215967..1216392 + 426 WP_000693855.1 toxin YdaT family protein -
QMG89_RS06045 (1216599) 1216599..1217054 - 456 WP_000273724.1 hypothetical protein -
QMG89_RS06050 (1217133) 1217133..1218248 + 1116 WP_001205821.1 hypothetical protein -
QMG89_RS06055 (1218255) 1218255..1219001 + 747 WP_000788742.1 ATP-binding protein -
QMG89_RS06060 (1219023) 1219023..1219793 + 771 WP_000451007.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T43397 WP_001303876.1 NZ_AP027191:c1214982-1214695 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T43397 NZ_AP027191:c1214982-1214695 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT43397 WP_000536233.1 NZ_AP027191:c1215173-1214982 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT43397 NZ_AP027191:c1215173-1214982 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References