Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3517201..3517826 Replicon chromosome
Accession NZ_AP027188
Organism Escherichia coli strain PV0838

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QMG68_RS18630 Protein ID WP_000911330.1
Coordinates 3517201..3517599 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag QMG68_RS18635 Protein ID WP_000450524.1
Coordinates 3517599..3517826 (-) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG68_RS18610 (3513079) 3513079..3513279 + 201 WP_000383836.1 YpfN family protein -
QMG68_RS18615 (3513389) 3513389..3514087 - 699 WP_000679806.1 esterase -
QMG68_RS18620 (3514161) 3514161..3516176 - 2016 WP_000829332.1 tRNA cytosine(34) acetyltransferase TmcA -
QMG68_RS18625 (3516191) 3516191..3517054 - 864 WP_001267508.1 neutral zinc metallopeptidase -
QMG68_RS18630 (3517201) 3517201..3517599 - 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
QMG68_RS18635 (3517599) 3517599..3517826 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
QMG68_RS18640 (3517980) 3517980..3518693 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QMG68_RS18645 (3518906) 3518906..3519940 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
QMG68_RS18650 (3519957) 3519957..3520835 - 879 WP_001311023.1 4-hydroxy-tetrahydrodipicolinate synthase -
QMG68_RS18655 (3520981) 3520981..3521553 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
QMG68_RS18660 (3521553) 3521553..3522023 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-125)

Antitoxin

(7-52)


Sequences


Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T43382 WP_000911330.1 NZ_AP027188:c3517599-3517201 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T43382 NZ_AP027188:c3517599-3517201 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT43382 WP_000450524.1 NZ_AP027188:c3517826-3517599 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT43382 NZ_AP027188:c3517826-3517599 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References