Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2901485..2902320 Replicon chromosome
Accession NZ_AP027188
Organism Escherichia coli strain PV0838

Toxin (Protein)


Gene name yeeV Uniprot ID A0A136X5A2
Locus tag QMG68_RS15510 Protein ID WP_000854757.1
Coordinates 2901943..2902320 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag QMG68_RS15505 Protein ID WP_001295723.1
Coordinates 2901485..2901853 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG68_RS15465 (2897592) 2897592..2897939 - 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
QMG68_RS15470 (2897936) 2897936..2898340 - 405 WP_000839179.1 transposase -
QMG68_RS15475 (2898420) 2898420..2898770 + 351 Protein_3032 IrmA family protein -
QMG68_RS15480 (2898849) 2898849..2899082 + 234 WP_001119729.1 DUF905 family protein -
QMG68_RS15485 (2899182) 2899182..2900000 + 819 WP_001234620.1 DUF932 domain-containing protein -
QMG68_RS15490 (2900055) 2900055..2900540 + 486 WP_000849582.1 antirestriction protein -
QMG68_RS15495 (2900556) 2900556..2901032 + 477 WP_001186725.1 RadC family protein -
QMG68_RS15500 (2901101) 2901101..2901322 + 222 WP_000692323.1 DUF987 domain-containing protein -
QMG68_RS15505 (2901485) 2901485..2901853 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QMG68_RS15510 (2901943) 2901943..2902320 + 378 WP_000854757.1 TA system toxin CbtA family protein Toxin
QMG68_RS15515 (2902317) 2902317..2902466 + 150 Protein_3040 DUF5983 family protein -
QMG68_RS15520 (2902566) 2902566..2902646 + 81 Protein_3041 hypothetical protein -
QMG68_RS15525 (2903462) 2903462..2903833 + 372 WP_001295631.1 IS110 family transposase -
QMG68_RS15530 (2904104) 2904104..2904469 + 366 WP_001282181.1 EutP/PduV family microcompartment system protein -
QMG68_RS15535 (2904570) 2904570..2904899 - 330 WP_000450409.1 DUF496 family protein -
QMG68_RS15540 (2905071) 2905071..2906129 - 1059 WP_001200887.1 FUSC family protein -
QMG68_RS15545 (2906327) 2906327..2906800 - 474 WP_001105384.1 DNA gyrase inhibitor SbmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14153.18 Da        Isoelectric Point: 7.3249

>T43380 WP_000854757.1 NZ_AP027188:2901943-2902320 [Escherichia coli]
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T43380 NZ_AP027188:2901943-2902320 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT43380 WP_001295723.1 NZ_AP027188:2901485-2901853 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT43380 NZ_AP027188:2901485-2901853 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A136X5A2

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References