Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2635846..2636317 Replicon chromosome
Accession NZ_AP027188
Organism Escherichia coli strain PV0838

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A1Y2Y8G6
Locus tag QMG68_RS14115 Protein ID WP_001448501.1
Coordinates 2636039..2636317 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QMG68_RS14110 Protein ID WP_001302048.1
Coordinates 2635846..2636037 (+) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG68_RS14060 (2630924) 2630924..2631142 - 219 WP_000683609.1 DUF4014 family protein -
QMG68_RS14065 (2631270) 2631270..2631581 - 312 WP_001289673.1 hypothetical protein -
QMG68_RS14070 (2631574) 2631574..2631801 - 228 WP_000699809.1 hypothetical protein -
QMG68_RS14075 (2631798) 2631798..2632079 - 282 WP_000603384.1 DNA-binding protein -
QMG68_RS14080 (2632112) 2632112..2632873 - 762 WP_000450872.1 DUF1627 domain-containing protein -
QMG68_RS14085 (2632899) 2632899..2633640 - 742 Protein_2762 ATP-binding protein -
QMG68_RS14090 (2633647) 2633647..2634609 - 963 WP_001444941.1 helix-turn-helix domain-containing protein -
QMG68_RS14095 (2634632) 2634632..2635057 - 426 WP_000693943.1 toxin YdaT family protein -
QMG68_RS14100 (2635054) 2635054..2635356 - 303 WP_000172738.1 transcriptional regulator -
QMG68_RS14105 (2635454) 2635454..2635825 + 372 WP_001169687.1 hypothetical protein -
QMG68_RS14110 (2635846) 2635846..2636037 + 192 WP_001302048.1 hypothetical protein Antitoxin
QMG68_RS14115 (2636039) 2636039..2636317 + 279 WP_001448501.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QMG68_RS14120 (2636604) 2636604..2636756 + 153 WP_001427316.1 DUF1391 family protein -
QMG68_RS14125 (2637177) 2637177..2637398 + 222 WP_000560218.1 killing protein KilR -
QMG68_RS14130 (2637398) 2637398..2637568 + 171 WP_001427414.1 YdaE family protein -
QMG68_RS14135 (2637642) 2637642..2637917 + 276 WP_001307773.1 hypothetical protein -
QMG68_RS14140 (2638016) 2638016..2640667 + 2652 WP_000105101.1 exodeoxyribonuclease VIII -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - nleG7' 2578220..2651105 72885


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10691.27 Da        Isoelectric Point: 5.5647

>T43371 WP_001448501.1 NZ_AP027188:2636039-2636317 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPSLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T43371 NZ_AP027188:2636039-2636317 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTAGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT43371 WP_001302048.1 NZ_AP027188:2635846-2636037 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT43371 NZ_AP027188:2635846-2636037 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1Y2Y8G6


Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References