Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | paaR-paaA-parE/- |
Location | 2635846..2636317 | Replicon | chromosome |
Accession | NZ_AP027188 | ||
Organism | Escherichia coli strain PV0838 |
Toxin (Protein)
Gene name | parE_1 | Uniprot ID | A0A1Y2Y8G6 |
Locus tag | QMG68_RS14115 | Protein ID | WP_001448501.1 |
Coordinates | 2636039..2636317 (+) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | paaA | Uniprot ID | Q8XAD5 |
Locus tag | QMG68_RS14110 | Protein ID | WP_001302048.1 |
Coordinates | 2635846..2636037 (+) | Length | 64 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QMG68_RS14060 (2630924) | 2630924..2631142 | - | 219 | WP_000683609.1 | DUF4014 family protein | - |
QMG68_RS14065 (2631270) | 2631270..2631581 | - | 312 | WP_001289673.1 | hypothetical protein | - |
QMG68_RS14070 (2631574) | 2631574..2631801 | - | 228 | WP_000699809.1 | hypothetical protein | - |
QMG68_RS14075 (2631798) | 2631798..2632079 | - | 282 | WP_000603384.1 | DNA-binding protein | - |
QMG68_RS14080 (2632112) | 2632112..2632873 | - | 762 | WP_000450872.1 | DUF1627 domain-containing protein | - |
QMG68_RS14085 (2632899) | 2632899..2633640 | - | 742 | Protein_2762 | ATP-binding protein | - |
QMG68_RS14090 (2633647) | 2633647..2634609 | - | 963 | WP_001444941.1 | helix-turn-helix domain-containing protein | - |
QMG68_RS14095 (2634632) | 2634632..2635057 | - | 426 | WP_000693943.1 | toxin YdaT family protein | - |
QMG68_RS14100 (2635054) | 2635054..2635356 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
QMG68_RS14105 (2635454) | 2635454..2635825 | + | 372 | WP_001169687.1 | hypothetical protein | - |
QMG68_RS14110 (2635846) | 2635846..2636037 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
QMG68_RS14115 (2636039) | 2636039..2636317 | + | 279 | WP_001448501.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
QMG68_RS14120 (2636604) | 2636604..2636756 | + | 153 | WP_001427316.1 | DUF1391 family protein | - |
QMG68_RS14125 (2637177) | 2637177..2637398 | + | 222 | WP_000560218.1 | killing protein KilR | - |
QMG68_RS14130 (2637398) | 2637398..2637568 | + | 171 | WP_001427414.1 | YdaE family protein | - |
QMG68_RS14135 (2637642) | 2637642..2637917 | + | 276 | WP_001307773.1 | hypothetical protein | - |
QMG68_RS14140 (2638016) | 2638016..2640667 | + | 2652 | WP_000105101.1 | exodeoxyribonuclease VIII | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | nleG7' | 2578220..2651105 | 72885 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10691.27 Da Isoelectric Point: 5.5647
>T43371 WP_001448501.1 NZ_AP027188:2636039-2636317 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPSLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPSLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T43371 NZ_AP027188:2636039-2636317 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTAGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTAGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT43371 WP_001302048.1 NZ_AP027188:2635846-2636037 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT43371 NZ_AP027188:2635846-2636037 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1Y2Y8G6 |
Antitoxin
Source | ID | Structure |
---|---|---|
PDB | 5CZF | |
PDB | 3ZBE | |
PDB | 5CW7 | |
AlphaFold DB | A0A829CTP0 |