Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1212623..1213101 Replicon chromosome
Accession NZ_AP027188
Organism Escherichia coli strain PV0838

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag QMG68_RS06000 Protein ID WP_001303876.1
Coordinates 1212623..1212910 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag QMG68_RS06005 Protein ID WP_000536233.1
Coordinates 1212910..1213101 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG68_RS05970 (1207846) 1207846..1210296 - 2451 WP_000048583.1 exonuclease -
QMG68_RS05975 (1210390) 1210390..1210581 - 192 WP_001098307.1 DUF1482 family protein -
QMG68_RS05980 (1210578) 1210578..1210766 - 189 WP_000413705.1 cell division inhibition protein DicB -
QMG68_RS05985 (1211334) 1211334..1211543 + 210 WP_001133037.1 hypothetical protein -
QMG68_RS05990 (1211544) 1211544..1212182 - 639 WP_000394543.1 hypothetical protein -
QMG68_RS05995 (1212194) 1212194..1212346 - 153 WP_000380316.1 DUF1391 family protein -
QMG68_RS06000 (1212623) 1212623..1212910 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QMG68_RS06005 (1212910) 1212910..1213101 - 192 WP_000536233.1 hypothetical protein Antitoxin
QMG68_RS06010 (1213129) 1213129..1213530 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
QMG68_RS06015 (1213639) 1213639..1213911 + 273 WP_000887453.1 YdaS family helix-turn-helix protein -
QMG68_RS06020 (1213895) 1213895..1214320 + 426 WP_000693855.1 toxin YdaT family protein -
QMG68_RS06025 (1214527) 1214527..1214982 - 456 WP_000273724.1 hypothetical protein -
QMG68_RS06030 (1215061) 1215061..1216176 + 1116 WP_001205821.1 hypothetical protein -
QMG68_RS06035 (1216183) 1216183..1216929 + 747 WP_000788742.1 ATP-binding protein -
QMG68_RS06040 (1216951) 1216951..1217721 + 771 WP_000451007.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - espFu/tccP 1206539..1305851 99312


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T43364 WP_001303876.1 NZ_AP027188:c1212910-1212623 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T43364 NZ_AP027188:c1212910-1212623 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT43364 WP_000536233.1 NZ_AP027188:c1213101-1212910 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT43364 NZ_AP027188:c1213101-1212910 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References