Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 5630565..5631397 | Replicon | chromosome |
| Accession | NZ_AP027185 | ||
| Organism | Escherichia coli strain NIID080884 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1PD64 |
| Locus tag | QMG74_RS28690 | Protein ID | WP_000854753.1 |
| Coordinates | 5631023..5631397 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | V0ULY5 |
| Locus tag | QMG74_RS28685 | Protein ID | WP_001315620.1 |
| Coordinates | 5630565..5630933 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMG74_RS28650 (5626295) | 5626295..5627451 | + | 1157 | WP_085948186.1 | IS3-like element IS600 family transposase | - |
| QMG74_RS28655 (5627488) | 5627488..5627856 | + | 369 | Protein_5594 | IrmA family protein | - |
| QMG74_RS28660 (5627935) | 5627935..5628168 | + | 234 | WP_001119729.1 | DUF905 family protein | - |
| QMG74_RS28665 (5628268) | 5628268..5629086 | + | 819 | WP_001234622.1 | DUF932 domain-containing protein | - |
| QMG74_RS28670 (5629141) | 5629141..5629626 | + | 486 | WP_000849588.1 | antirestriction protein | - |
| QMG74_RS28675 (5629642) | 5629642..5630118 | + | 477 | WP_001186774.1 | RadC family protein | - |
| QMG74_RS28680 (5630181) | 5630181..5630402 | + | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
| QMG74_RS28685 (5630565) | 5630565..5630933 | + | 369 | WP_001315620.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| QMG74_RS28690 (5631023) | 5631023..5631397 | + | 375 | WP_000854753.1 | TA system toxin CbtA family protein | Toxin |
| QMG74_RS28695 (5631394) | 5631394..5631882 | + | 489 | WP_000777547.1 | DUF5983 family protein | - |
| QMG74_RS28700 (5631894) | 5631894..5632091 | + | 198 | WP_000839281.1 | DUF957 domain-containing protein | - |
| QMG74_RS28705 (5632176) | 5632176..5632325 | + | 150 | Protein_5604 | restriction endonuclease subunit M | - |
| QMG74_RS28710 (5633093) | 5633093..5633236 | - | 144 | Protein_5605 | HNH endonuclease | - |
| QMG74_RS28715 (5633373) | 5633373..5634023 | + | 651 | WP_001037966.1 | HNH endonuclease | - |
| QMG74_RS28720 (5634031) | 5634031..5635011 | - | 981 | WP_000991415.1 | sialate O-acetylesterase | - |
| QMG74_RS28725 (5635076) | 5635076..5635233 | - | 158 | Protein_5608 | N-acetylneuraminic acid mutarotase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | fimB / fimE / fimA / fimI / fimC / fimD / fimF / fimG / fimH | 5625008..5653935 | 28927 | |
| - | flank | IS/Tn | - | - | 5635215..5636423 | 1208 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14005.00 Da Isoelectric Point: 8.2905
>T43355 WP_000854753.1 NZ_AP027185:5631023-5631397 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
Download Length: 375 bp
>T43355 NZ_AP027185:5631023-5631397 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13474.20 Da Isoelectric Point: 6.2050
>AT43355 WP_001315620.1 NZ_AP027185:5630565-5630933 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
Download Length: 369 bp
>AT43355 NZ_AP027185:5630565-5630933 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9LVU0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V0ULY5 |