Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2788097..2788932 Replicon chromosome
Accession NZ_AP027185
Organism Escherichia coli strain NIID080884

Toxin (Protein)


Gene name yeeV Uniprot ID A0A136X5A2
Locus tag QMG74_RS14470 Protein ID WP_000854757.1
Coordinates 2788555..2788932 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag QMG74_RS14465 Protein ID WP_001295723.1
Coordinates 2788097..2788465 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG74_RS14425 (2784204) 2784204..2784551 - 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
QMG74_RS14430 (2784548) 2784548..2784952 - 405 WP_000839179.1 transposase -
QMG74_RS14435 (2785032) 2785032..2785382 + 351 Protein_2826 IrmA family protein -
QMG74_RS14440 (2785461) 2785461..2785694 + 234 WP_001119729.1 DUF905 family protein -
QMG74_RS14445 (2785794) 2785794..2786612 + 819 WP_001234620.1 DUF932 domain-containing protein -
QMG74_RS14450 (2786667) 2786667..2787152 + 486 WP_000849582.1 antirestriction protein -
QMG74_RS14455 (2787168) 2787168..2787644 + 477 WP_001186725.1 RadC family protein -
QMG74_RS14460 (2787713) 2787713..2787934 + 222 WP_000692323.1 DUF987 domain-containing protein -
QMG74_RS14465 (2788097) 2788097..2788465 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QMG74_RS14470 (2788555) 2788555..2788932 + 378 WP_000854757.1 TA system toxin CbtA family protein Toxin
QMG74_RS14475 (2788929) 2788929..2789078 + 150 Protein_2834 DUF5983 family protein -
QMG74_RS14480 (2789178) 2789178..2789258 + 81 Protein_2835 hypothetical protein -
QMG74_RS14485 (2790074) 2790074..2790445 + 372 WP_001295631.1 IS110 family transposase -
QMG74_RS14490 (2790716) 2790716..2791081 + 366 WP_001282181.1 EutP/PduV family microcompartment system protein -
QMG74_RS14495 (2791182) 2791182..2791511 - 330 WP_000450409.1 DUF496 family protein -
QMG74_RS14500 (2791683) 2791683..2792741 - 1059 WP_001200887.1 FUSC family protein -
QMG74_RS14505 (2792939) 2792939..2793412 - 474 WP_001105384.1 DNA gyrase inhibitor SbmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14153.18 Da        Isoelectric Point: 7.3249

>T43345 WP_000854757.1 NZ_AP027185:2788555-2788932 [Escherichia coli]
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T43345 NZ_AP027185:2788555-2788932 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT43345 WP_001295723.1 NZ_AP027185:2788097-2788465 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT43345 NZ_AP027185:2788097-2788465 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A136X5A2

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References