Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1251871..1252349 Replicon chromosome
Accession NZ_AP027185
Organism Escherichia coli strain NIID080884

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag QMG74_RS06115 Protein ID WP_001303876.1
Coordinates 1251871..1252158 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag QMG74_RS06120 Protein ID WP_000536233.1
Coordinates 1252158..1252349 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG74_RS06085 (1247094) 1247094..1249544 - 2451 WP_000048583.1 exonuclease -
QMG74_RS06090 (1249638) 1249638..1249829 - 192 WP_001098307.1 DUF1482 family protein -
QMG74_RS06095 (1249826) 1249826..1250014 - 189 WP_000413705.1 cell division inhibition protein DicB -
QMG74_RS06100 (1250582) 1250582..1250791 + 210 WP_001133037.1 hypothetical protein -
QMG74_RS06105 (1250792) 1250792..1251430 - 639 WP_000394543.1 hypothetical protein -
QMG74_RS06110 (1251442) 1251442..1251594 - 153 WP_000380316.1 DUF1391 family protein -
QMG74_RS06115 (1251871) 1251871..1252158 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QMG74_RS06120 (1252158) 1252158..1252349 - 192 WP_000536233.1 hypothetical protein Antitoxin
QMG74_RS06125 (1252377) 1252377..1252778 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
QMG74_RS06130 (1252887) 1252887..1253159 + 273 WP_000887453.1 YdaS family helix-turn-helix protein -
QMG74_RS06135 (1253143) 1253143..1253568 + 426 WP_000693855.1 toxin YdaT family protein -
QMG74_RS06140 (1253775) 1253775..1254230 - 456 WP_000273724.1 hypothetical protein -
QMG74_RS06145 (1254309) 1254309..1255424 + 1116 WP_001205821.1 hypothetical protein -
QMG74_RS06150 (1255431) 1255431..1256177 + 747 WP_000788742.1 ATP-binding protein -
QMG74_RS06155 (1256199) 1256199..1256969 + 771 WP_000451007.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T43330 WP_001303876.1 NZ_AP027185:c1252158-1251871 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T43330 NZ_AP027185:c1252158-1251871 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT43330 WP_000536233.1 NZ_AP027185:c1252349-1252158 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT43330 NZ_AP027185:c1252349-1252158 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References