Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 64711..65312 Replicon plasmid pO26_98E11_1
Accession NZ_AP027182
Organism Escherichia coli strain 98E11

Toxin (Protein)


Gene name doc Uniprot ID U9Z1Q0
Locus tag QMG82_RS29935 Protein ID WP_001216047.1
Coordinates 64711..65091 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag QMG82_RS29940 Protein ID WP_001190712.1
Coordinates 65091..65312 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG82_RS29905 59841..60071 - 231 Protein_57 ash family protein -
QMG82_RS29910 (F98E11_p1_061) 60142..61635 - 1494 WP_024222340.1 terminase -
QMG82_RS29915 (F98E11_p1_062) 61635..62828 - 1194 WP_024222339.1 hypothetical protein -
QMG82_RS29920 (F98E11_p1_063) 62915..63337 - 423 WP_000405089.1 hypothetical protein -
QMG82_RS29925 (F98E11_p1_064) 63456..64499 - 1044 WP_000644102.1 DUF968 domain-containing protein -
QMG82_RS29930 (F98E11_p1_065) 64527..64706 - 180 WP_000113019.1 hypothetical protein -
QMG82_RS29935 (F98E11_p1_066) 64711..65091 - 381 WP_001216047.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
QMG82_RS29940 (F98E11_p1_067) 65091..65312 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QMG82_RS29945 (F98E11_p1_068) 65385..65774 - 390 WP_000506726.1 S24 family peptidase -
QMG82_RS29950 (F98E11_p1_069) 65898..66149 - 252 WP_001283837.1 DNA polymerase III subunit theta -
QMG82_RS29955 (F98E11_p1_070) 66182..66532 + 351 WP_000551789.1 hypothetical protein -
QMG82_RS29960 (F98E11_p1_071) 66517..66801 - 285 WP_001142394.1 hypothetical protein -
QMG82_RS29965 (F98E11_p1_072) 66785..67435 - 651 WP_000057451.1 hypothetical protein -
QMG82_RS29970 (F98E11_p1_073) 67417..67791 - 375 WP_032346478.1 hypothetical protein -
QMG82_RS29975 (F98E11_p1_074) 67798..68091 - 294 WP_000269004.1 hypothetical protein -
QMG82_RS29980 (F98E11_p1_076) 68270..68503 - 234 WP_032346477.1 hypothetical protein -
QMG82_RS29985 68586..68774 - 189 WP_032352565.1 DUF551 domain-containing protein -
QMG82_RS29990 68862..69125 - 264 Protein_74 hypothetical protein -
QMG82_RS29995 69342..69476 - 135 Protein_75 DUF551 domain-containing protein -
QMG82_RS30000 69836..69988 - 153 Protein_76 hypothetical protein -
QMG82_RS30005 (F98E11_p1_079) 69990..70178 - 189 WP_000797279.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..99281 99281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13574.27 Da        Isoelectric Point: 5.1514

>T43324 WP_001216047.1 NZ_AP027182:c65091-64711 [Escherichia coli]
MRHISPEELVALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

>T43324 NZ_AP027182:c65091-64711 [Escherichia coli]
ATGAGACATATATCACCGGAAGAACTTGTTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACTGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT43324 WP_001190712.1 NZ_AP027182:c65312-65091 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp

>AT43324 NZ_AP027182:c65312-65091 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGTGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9Z1Q0

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References