Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3936592..3937246 Replicon chromosome
Accession NZ_AP027181
Organism Escherichia coli strain 98E11

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag QMG82_RS20510 Protein ID WP_000244777.1
Coordinates 3936592..3936999 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QMG82_RS20515 Protein ID WP_000354046.1
Coordinates 3936980..3937246 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG82_RS20490 (3932549) 3932549..3934282 - 1734 WP_000813220.1 single-stranded-DNA-specific exonuclease RecJ -
QMG82_RS20495 (3934288) 3934288..3934998 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QMG82_RS20500 (3935023) 3935023..3935919 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QMG82_RS20505 (3936031) 3936031..3936552 + 522 WP_001055874.1 flavodoxin FldB -
QMG82_RS20510 (3936592) 3936592..3936999 - 408 WP_000244777.1 protein YgfX Toxin
QMG82_RS20515 (3936980) 3936980..3937246 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QMG82_RS20520 (3937489) 3937489..3938469 + 981 WP_000886095.1 tRNA-modifying protein YgfZ -
QMG82_RS20525 (3938665) 3938665..3939324 - 660 WP_000250274.1 hemolysin III family protein -
QMG82_RS20530 (3939488) 3939488..3939799 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
QMG82_RS20535 (3939844) 3939844..3941277 + 1434 WP_001341859.1 6-phospho-beta-glucosidase BglA -
QMG82_RS20540 (3941334) 3941334..3942077 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T43316 WP_000244777.1 NZ_AP027181:c3936999-3936592 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T43316 NZ_AP027181:c3936999-3936592 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT43316 WP_000354046.1 NZ_AP027181:c3937246-3936980 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT43316 NZ_AP027181:c3937246-3936980 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References