Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2784087..2784922 Replicon chromosome
Accession NZ_AP027181
Organism Escherichia coli strain 98E11

Toxin (Protein)


Gene name yeeV Uniprot ID A0A136X5A2
Locus tag QMG82_RS14670 Protein ID WP_000854757.1
Coordinates 2784545..2784922 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag QMG82_RS14665 Protein ID WP_001295723.1
Coordinates 2784087..2784455 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG82_RS14625 (2780194) 2780194..2780541 - 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
QMG82_RS14630 (2780538) 2780538..2780942 - 405 WP_000839179.1 transposase -
QMG82_RS14635 (2781022) 2781022..2781372 + 351 Protein_2870 IrmA family protein -
QMG82_RS14640 (2781451) 2781451..2781684 + 234 WP_001119729.1 DUF905 family protein -
QMG82_RS14645 (2781784) 2781784..2782602 + 819 WP_001234620.1 DUF932 domain-containing protein -
QMG82_RS14650 (2782657) 2782657..2783142 + 486 WP_000849582.1 antirestriction protein -
QMG82_RS14655 (2783158) 2783158..2783634 + 477 WP_001186725.1 RadC family protein -
QMG82_RS14660 (2783703) 2783703..2783924 + 222 WP_000692323.1 DUF987 domain-containing protein -
QMG82_RS14665 (2784087) 2784087..2784455 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QMG82_RS14670 (2784545) 2784545..2784922 + 378 WP_000854757.1 TA system toxin CbtA family protein Toxin
QMG82_RS14675 (2784919) 2784919..2785068 + 150 Protein_2878 DUF5983 family protein -
QMG82_RS14680 (2785168) 2785168..2785248 + 81 Protein_2879 hypothetical protein -
QMG82_RS14685 (2786064) 2786064..2786435 + 372 WP_001295631.1 IS110 family transposase -
QMG82_RS14690 (2786706) 2786706..2787071 + 366 WP_001282181.1 EutP/PduV family microcompartment system protein -
QMG82_RS14695 (2787172) 2787172..2787501 - 330 WP_000450409.1 DUF496 family protein -
QMG82_RS14700 (2787673) 2787673..2788731 - 1059 WP_001200887.1 FUSC family protein -
QMG82_RS14705 (2788929) 2788929..2789402 - 474 WP_001105384.1 DNA gyrase inhibitor SbmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14153.18 Da        Isoelectric Point: 7.3249

>T43311 WP_000854757.1 NZ_AP027181:2784545-2784922 [Escherichia coli]
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T43311 NZ_AP027181:2784545-2784922 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT43311 WP_001295723.1 NZ_AP027181:2784087-2784455 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT43311 NZ_AP027181:2784087-2784455 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A136X5A2

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References