Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2206834..2207360 | Replicon | chromosome |
| Accession | NZ_AP027181 | ||
| Organism | Escherichia coli strain 98E11 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | QMG82_RS11645 | Protein ID | WP_000323025.1 |
| Coordinates | 2206834..2207121 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | QMG82_RS11650 | Protein ID | WP_000534858.1 |
| Coordinates | 2207121..2207360 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMG82_RS11595 (2201858) | 2201858..2202073 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| QMG82_RS11600 (2202293) | 2202293..2202463 | + | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| QMG82_RS11605 (2202827) | 2202827..2203042 | - | 216 | WP_000066483.1 | cold shock-like protein CspB | - |
| QMG82_RS11610 (2203343) | 2203343..2203555 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| QMG82_RS11615 (2203610) | 2203610..2203699 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| QMG82_RS11620 (2203977) | 2203977..2204729 | - | 753 | WP_001047133.1 | antitermination protein | - |
| QMG82_RS11625 (2204743) | 2204743..2205792 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| QMG82_RS11630 (2205794) | 2205794..2206072 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| QMG82_RS11635 (2206139) | 2206139..2206390 | - | 252 | WP_000980994.1 | protein Rem | - |
| QMG82_RS11640 (2206607) | 2206607..2206762 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| QMG82_RS11645 (2206834) | 2206834..2207121 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| QMG82_RS11650 (2207121) | 2207121..2207360 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| QMG82_RS11655 (2207385) | 2207385..2207690 | + | 306 | WP_001326990.1 | protein YdfV | - |
| QMG82_RS11660 (2207893) | 2207893..2208225 | + | 333 | WP_001317460.1 | FlxA-like family protein | - |
| QMG82_RS11665 (2208662) | 2208662..2208811 | - | 150 | WP_180302674.1 | protein YdfW | - |
| QMG82_RS11670 (2208884) | 2208884..2209981 | - | 1098 | Protein_2288 | ISNCY family transposase | - |
| QMG82_RS11675 (2210036) | 2210036..2210455 | - | 420 | WP_001151195.1 | DUF977 family protein | - |
| QMG82_RS11680 (2210496) | 2210496..2211461 | - | 966 | WP_000054507.1 | hypothetical protein | - |
| QMG82_RS11685 (2211442) | 2211442..2211963 | - | 522 | WP_000705349.1 | toxin YdaT family protein | - |
| QMG82_RS11690 (2211947) | 2211947..2212174 | - | 228 | WP_000476993.1 | Cro/CI family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2171071..2226520 | 55449 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T43301 WP_000323025.1 NZ_AP027181:c2207121-2206834 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T43301 NZ_AP027181:c2207121-2206834 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT43301 WP_000534858.1 NZ_AP027181:c2207360-2207121 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT43301 NZ_AP027181:c2207360-2207121 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|