Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1176599..1177077 Replicon chromosome
Accession NZ_AP027181
Organism Escherichia coli strain 98E11

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag QMG82_RS05730 Protein ID WP_001303876.1
Coordinates 1176599..1176886 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag QMG82_RS05735 Protein ID WP_000536233.1
Coordinates 1176886..1177077 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG82_RS05700 (1171822) 1171822..1174272 - 2451 WP_000048583.1 exonuclease -
QMG82_RS05705 (1174366) 1174366..1174557 - 192 WP_001098307.1 DUF1482 family protein -
QMG82_RS05710 (1174554) 1174554..1174742 - 189 WP_000413705.1 cell division inhibition protein DicB -
QMG82_RS05715 (1175310) 1175310..1175519 + 210 WP_001133037.1 hypothetical protein -
QMG82_RS05720 (1175520) 1175520..1176158 - 639 WP_000394543.1 hypothetical protein -
QMG82_RS05725 (1176170) 1176170..1176322 - 153 WP_000380316.1 DUF1391 family protein -
QMG82_RS05730 (1176599) 1176599..1176886 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QMG82_RS05735 (1176886) 1176886..1177077 - 192 WP_000536233.1 hypothetical protein Antitoxin
QMG82_RS05740 (1177105) 1177105..1177506 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
QMG82_RS05745 (1177615) 1177615..1177887 + 273 WP_000887453.1 YdaS family helix-turn-helix protein -
QMG82_RS05750 (1177871) 1177871..1178296 + 426 WP_000693855.1 toxin YdaT family protein -
QMG82_RS05755 (1178503) 1178503..1178958 - 456 WP_000273724.1 hypothetical protein -
QMG82_RS05760 (1179037) 1179037..1180152 + 1116 WP_001205821.1 hypothetical protein -
QMG82_RS05765 (1180159) 1180159..1180905 + 747 WP_000788742.1 ATP-binding protein -
QMG82_RS05770 (1180927) 1180927..1181697 + 771 WP_000451007.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T43291 WP_001303876.1 NZ_AP027181:c1176886-1176599 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T43291 NZ_AP027181:c1176886-1176599 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT43291 WP_000536233.1 NZ_AP027181:c1177077-1176886 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT43291 NZ_AP027181:c1177077-1176886 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References