Detailed information of TA system TA043272

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4020586..4021240
• Replicon: chromosome
• Accession: NZ_AP027176
• Organism: Escherichia coli strain EH2252

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: S1EEB2
• Locus tag: QMG71_RS20985
• Protein ID: WP_000244777.1
• Coordinates: 4020586..4020993 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: QMG71_RS20990
• Protein ID: WP_000354043.1
• Coordinates: 4020974..4021240 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMG71_RS20965 (4016543)	4016543..4018276	-	1734	WP_000813220.1	single-stranded-DNA-specific exonuclease RecJ	-
QMG71_RS20970 (4018282)	4018282..4018992	-	711	WP_000715214.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
QMG71_RS20975 (4019017)	4019017..4019913	-	897	WP_000806638.1	site-specific tyrosine recombinase XerD	-
QMG71_RS20980 (4020025)	4020025..4020546	+	522	WP_001055874.1	flavodoxin FldB	-
QMG71_RS20985 (4020586)	4020586..4020993	-	408	WP_000244777.1	protein YgfX	Toxin
QMG71_RS20990 (4020974)	4020974..4021240	-	267	WP_000354043.1	FAD assembly factor SdhE	Antitoxin
QMG71_RS20995 (4021483)	4021483..4022463	+	981	WP_000886095.1	tRNA-modifying protein YgfZ	-
QMG71_RS21000 (4022659)	4022659..4023318	-	660	WP_000250274.1	hemolysin III family protein	-
QMG71_RS21005 (4023482)	4023482..4023793	-	312	WP_001182954.1	N(4)-acetylcytidine aminohydrolase	-
QMG71_RS21010 (4023838)	4023838..4025271	+	1434	WP_001341859.1	6-phospho-beta-glucosidase BglA	-
QMG71_RS21015 (4025328)	4025328..4026071	-	744	WP_000951964.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 16031.96 Da
• Isoelectric Point: 11.5202

>T43272 WP_000244777.1 NZ_AP027176:c4020993-4020586 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Nucleotide

• Length: 408 bp

>T43272 NZ_AP027176:c4020993-4020586 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10563.16 Da
• Isoelectric Point: 5.1599

>AT43272 WP_000354043.1 NZ_AP027176:c4021240-4020974 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDLDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT43272 NZ_AP027176:c4021240-4020974 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCTGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A7U9LFV7