Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2551299..2551770 | Replicon | chromosome |
| Accession | NZ_AP027176 | ||
| Organism | Escherichia coli strain EH2252 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | QMG71_RS13425 | Protein ID | WP_001303511.1 |
| Coordinates | 2551492..2551770 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | QMG71_RS13420 | Protein ID | WP_001302048.1 |
| Coordinates | 2551299..2551490 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMG71_RS13370 (2546377) | 2546377..2546595 | - | 219 | WP_000683609.1 | DUF4014 family protein | - |
| QMG71_RS13375 (2546723) | 2546723..2547034 | - | 312 | WP_001289673.1 | hypothetical protein | - |
| QMG71_RS13380 (2547027) | 2547027..2547254 | - | 228 | WP_000699809.1 | hypothetical protein | - |
| QMG71_RS13385 (2547251) | 2547251..2547532 | - | 282 | WP_000603384.1 | DNA-binding protein | - |
| QMG71_RS13390 (2547565) | 2547565..2548326 | - | 762 | WP_000450872.1 | DUF1627 domain-containing protein | - |
| QMG71_RS13395 (2548352) | 2548352..2549093 | - | 742 | Protein_2633 | ATP-binding protein | - |
| QMG71_RS13400 (2549100) | 2549100..2550062 | - | 963 | WP_001444941.1 | helix-turn-helix domain-containing protein | - |
| QMG71_RS13405 (2550085) | 2550085..2550510 | - | 426 | WP_000693943.1 | toxin YdaT family protein | - |
| QMG71_RS13410 (2550507) | 2550507..2550809 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
| QMG71_RS13415 (2550907) | 2550907..2551278 | + | 372 | WP_001169687.1 | hypothetical protein | - |
| QMG71_RS13420 (2551299) | 2551299..2551490 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| QMG71_RS13425 (2551492) | 2551492..2551770 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| QMG71_RS13430 (2552057) | 2552057..2552209 | + | 153 | WP_001427316.1 | DUF1391 family protein | - |
| QMG71_RS13435 (2552630) | 2552630..2552851 | + | 222 | WP_000560218.1 | killing protein KilR | - |
| QMG71_RS13440 (2552851) | 2552851..2553021 | + | 171 | WP_001427414.1 | YdaE family protein | - |
| QMG71_RS13445 (2553095) | 2553095..2553370 | + | 276 | WP_001307773.1 | hypothetical protein | - |
| QMG71_RS13450 (2553469) | 2553469..2556120 | + | 2652 | WP_000105101.1 | exodeoxyribonuclease VIII | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleG7' | 2501332..2564651 | 63319 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T43258 WP_001303511.1 NZ_AP027176:2551492-2551770 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T43258 NZ_AP027176:2551492-2551770 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT43258 WP_001302048.1 NZ_AP027176:2551299-2551490 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT43258 NZ_AP027176:2551299-2551490 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|