Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2229847..2230373 | Replicon | chromosome |
| Accession | NZ_AP027176 | ||
| Organism | Escherichia coli strain EH2252 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | QMG71_RS11705 | Protein ID | WP_000323025.1 |
| Coordinates | 2229847..2230134 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | QMG71_RS11710 | Protein ID | WP_000534858.1 |
| Coordinates | 2230134..2230373 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMG71_RS11655 (2224870) | 2224870..2225085 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| QMG71_RS11660 (2225305) | 2225305..2225475 | + | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| QMG71_RS11665 (2225839) | 2225839..2226054 | - | 216 | WP_000066483.1 | cold shock-like protein CspB | - |
| QMG71_RS11670 (2226355) | 2226355..2226567 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| QMG71_RS11675 (2226622) | 2226622..2226711 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| QMG71_RS11680 (2226989) | 2226989..2227742 | - | 754 | Protein_2293 | antitermination protein | - |
| QMG71_RS11685 (2227756) | 2227756..2228805 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| QMG71_RS11690 (2228807) | 2228807..2229085 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| QMG71_RS11695 (2229152) | 2229152..2229403 | - | 252 | WP_000980994.1 | protein Rem | - |
| QMG71_RS11700 (2229620) | 2229620..2229775 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| QMG71_RS11705 (2229847) | 2229847..2230134 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| QMG71_RS11710 (2230134) | 2230134..2230373 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| QMG71_RS11715 (2230398) | 2230398..2230703 | + | 306 | WP_001326990.1 | protein YdfV | - |
| QMG71_RS11720 (2230906) | 2230906..2231238 | + | 333 | WP_001317460.1 | FlxA-like family protein | - |
| QMG71_RS11725 (2231675) | 2231675..2231824 | - | 150 | WP_180302674.1 | protein YdfW | - |
| QMG71_RS11730 (2231897) | 2231897..2232994 | - | 1098 | Protein_2303 | ISNCY family transposase | - |
| QMG71_RS11735 (2233049) | 2233049..2233468 | - | 420 | WP_001151195.1 | DUF977 family protein | - |
| QMG71_RS11740 (2233509) | 2233509..2234474 | - | 966 | WP_000054507.1 | hypothetical protein | - |
| QMG71_RS11745 (2234455) | 2234455..2234976 | - | 522 | WP_000705349.1 | toxin YdaT family protein | - |
| QMG71_RS11750 (2234960) | 2234960..2235187 | - | 228 | WP_000476993.1 | Cro/CI family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2194512..2244501 | 49989 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T43257 WP_000323025.1 NZ_AP027176:c2230134-2229847 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T43257 NZ_AP027176:c2230134-2229847 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT43257 WP_000534858.1 NZ_AP027176:c2230373-2230134 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT43257 NZ_AP027176:c2230373-2230134 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|