Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1511253..1512088 | Replicon | chromosome |
| Accession | NZ_AP027176 | ||
| Organism | Escherichia coli strain EH2252 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A3U1IU51 |
| Locus tag | QMG71_RS07780 | Protein ID | WP_062878386.1 |
| Coordinates | 1511711..1512088 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A3T3WTI7 |
| Locus tag | QMG71_RS07775 | Protein ID | WP_062878385.1 |
| Coordinates | 1511253..1511621 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMG71_RS07740 (1508149) | 1508149..1508604 | + | 456 | WP_000581504.1 | IrmA family protein | - |
| QMG71_RS07745 (1508683) | 1508683..1508838 | + | 156 | WP_106422060.1 | DUF905 family protein | - |
| QMG71_RS07750 (1508826) | 1508826..1508972 | - | 147 | WP_265200957.1 | hypothetical protein | - |
| QMG71_RS07755 (1509015) | 1509015..1509833 | + | 819 | WP_001234620.1 | DUF932 domain-containing protein | - |
| QMG71_RS07760 (1509888) | 1509888..1510373 | + | 486 | WP_062887690.1 | antirestriction protein | - |
| QMG71_RS07765 (1510389) | 1510389..1510865 | + | 477 | WP_001186725.1 | RadC family protein | - |
| QMG71_RS07770 (1510952) | 1510952..1511173 | + | 222 | WP_000691818.1 | DUF987 domain-containing protein | - |
| QMG71_RS07775 (1511253) | 1511253..1511621 | + | 369 | WP_062878385.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| QMG71_RS07780 (1511711) | 1511711..1512088 | + | 378 | WP_062878386.1 | TA system toxin CbtA family protein | Toxin |
| QMG71_RS07785 (1512085) | 1512085..1512573 | + | 489 | WP_062878387.1 | DUF5983 family protein | - |
| QMG71_RS07790 (1512585) | 1512585..1512782 | + | 198 | WP_000839249.1 | DUF957 domain-containing protein | - |
| QMG71_RS07795 (1512867) | 1512867..1513427 | + | 561 | Protein_1523 | DUF4942 domain-containing protein | - |
| QMG71_RS07800 (1513499) | 1513499..1514502 | + | 1004 | Protein_1524 | IS110-like element ISSfl8 family transposase | - |
| QMG71_RS07805 (1514784) | 1514784..1515065 | + | 282 | Protein_1525 | DUF4942 domain-containing protein | - |
| QMG71_RS07815 (1515536) | 1515536..1516474 | + | 939 | WP_000351317.1 | glyoxylate/hydroxypyruvate reductase GhrA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 1513499..1513957 | 458 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14164.14 Da Isoelectric Point: 7.2922
>T43248 WP_062878386.1 NZ_AP027176:1511711-1512088 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNDITLGKHPEAKQ
MKTLPDTHVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNDITLGKHPEAKQ
Download Length: 378 bp
>T43248 NZ_AP027176:1511711-1512088 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAACTACAGAACGGTAAATGACATTACCCTGGGTAAGCATCCGGAGGCGAAACAATGA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAACTACAGAACGGTAAATGACATTACCCTGGGTAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13565.30 Da Isoelectric Point: 6.7340
>AT43248 WP_062878385.1 NZ_AP027176:1511253-1511621 [Escherichia coli]
VSDTFSGTTHPNDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLANRAGIRGRFSDADSYHLDQAFPLLMKQLEIMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGCVYLAVYPTPETKK
VSDTFSGTTHPNDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLANRAGIRGRFSDADSYHLDQAFPLLMKQLEIMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGCVYLAVYPTPETKK
Download Length: 369 bp
>AT43248 NZ_AP027176:1511253-1511621 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACGCATCCCAATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCTAACCGCGCAGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAAATCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGATACCCTCGGCAGCTG
TGGTTGCGTTTATCTGGCTGTTTATCCGACACCCGAAACGAAAAAGTAA
GTGTCAGACACATTCTCCGGGACAACGCATCCCAATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCTAACCGCGCAGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAAATCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGATACCCTCGGCAGCTG
TGGTTGCGTTTATCTGGCTGTTTATCCGACACCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3U1IU51 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3T3WTI7 |