Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1318426..1318904 Replicon chromosome
Accession NZ_AP027176
Organism Escherichia coli strain EH2252

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag QMG71_RS06655 Protein ID WP_001303876.1
Coordinates 1318426..1318713 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag QMG71_RS06660 Protein ID WP_000536233.1
Coordinates 1318713..1318904 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG71_RS06625 (1313649) 1313649..1316099 - 2451 WP_009448824.1 exonuclease -
QMG71_RS06630 (1316193) 1316193..1316384 - 192 WP_001098307.1 DUF1482 family protein -
QMG71_RS06635 (1316381) 1316381..1316569 - 189 WP_000413705.1 cell division inhibition protein DicB -
QMG71_RS06640 (1317137) 1317137..1317346 + 210 WP_001133037.1 hypothetical protein -
QMG71_RS06645 (1317347) 1317347..1317985 - 639 WP_000394543.1 hypothetical protein -
QMG71_RS06650 (1317997) 1317997..1318149 - 153 WP_000379552.1 DUF1391 family protein -
QMG71_RS06655 (1318426) 1318426..1318713 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QMG71_RS06660 (1318713) 1318713..1318904 - 192 WP_000536233.1 hypothetical protein Antitoxin
QMG71_RS06665 (1318932) 1318932..1319333 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
QMG71_RS06670 (1319442) 1319442..1319714 + 273 WP_000887453.1 YdaS family helix-turn-helix protein -
QMG71_RS06675 (1319698) 1319698..1320123 + 426 WP_000693855.1 toxin YdaT family protein -
QMG71_RS06680 (1320330) 1320330..1320785 - 456 WP_000273724.1 hypothetical protein -
QMG71_RS06685 (1320864) 1320864..1321979 + 1116 WP_001205820.1 hypothetical protein -
QMG71_RS06690 (1321986) 1321986..1322726 + 741 WP_021498074.1 ATP-binding protein -
QMG71_RS06695 (1322752) 1322752..1323522 + 771 WP_281919830.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T43247 WP_001303876.1 NZ_AP027176:c1318713-1318426 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T43247 NZ_AP027176:c1318713-1318426 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT43247 WP_000536233.1 NZ_AP027176:c1318904-1318713 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT43247 NZ_AP027176:c1318904-1318713 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References