Detailed information of TA system TA043237

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 36067..36614
• Replicon: plasmid pO26_20.1_1
• Accession: NZ_AP027171
• Organism: Escherichia coli strain 20.1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: QMG87_RS29095
• Protein ID: WP_097309154.1
• Coordinates: 36336..36614 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: E1QMW3
• Locus tag: QMG87_RS29090
• Protein ID: WP_000079941.1
• Coordinates: 36067..36336 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMG87_RS29080 (32838)	32838..34112	-	1275	WP_000489607.1	HlyD family secretion protein	-
QMG87_RS29085 (34309)	34309..35545	-	1237	Protein_44	IS3 family transposase	-
QMG87_RS29090 (36067)	36067..36336	+	270	WP_000079941.1	type II toxin-antitoxin system antitoxin YacA	Antitoxin
QMG87_RS29095 (36336)	36336..36614	+	279	WP_097309154.1	type II toxin-antitoxin system toxin YacB	Toxin
QMG87_RS29100 (36660)	36660..37508	+	849	WP_001058005.1	3'-5' exonuclease	-
QMG87_RS29105 (37625)	37625..38107	+	483	WP_001311056.1	hypothetical protein	-
QMG87_RS29110 (38409)	38409..38756	+	348	WP_000142437.1	DUF6404 family protein	-
QMG87_RS29115 (38834)	38834..39134	-	301	Protein_50	hypothetical protein	-
QMG87_RS29120 (39315)	39315..40349	+	1035	WP_001190234.1	3-deoxy-7-phosphoheptulonate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	aph(6)-Id / aph(3'')-Ib / sul2 / sitABCD	iroN / iroE / iroD / iroC / iroB	1..129563	129563

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10799.42 Da
• Isoelectric Point: 8.4615

>T43237 WP_097309154.1 NZ_AP027171:36336-36614 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGYSASNLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTVQKWP

Nucleotide

• Length: 279 bp

>T43237 NZ_AP027171:36336-36614 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATAGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAACCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGAGTATTGCATACTGTACAGAAGTGGCCATAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10252.58 Da
• Isoelectric Point: 7.2057

>AT43237 WP_000079941.1 NZ_AP027171:36067-36336 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Nucleotide

• Length: 270 bp

>AT43237 NZ_AP027171:36067-36336 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATTGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTACTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAAGTCGCCGGTAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A629TXC5