Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2774961..2775796 | Replicon | chromosome |
| Accession | NZ_AP027170 | ||
| Organism | Escherichia coli strain 20.1 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A136X5A2 |
| Locus tag | QMG87_RS14635 | Protein ID | WP_000854757.1 |
| Coordinates | 2775419..2775796 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1NM52 |
| Locus tag | QMG87_RS14630 | Protein ID | WP_001295723.1 |
| Coordinates | 2774961..2775329 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMG87_RS14590 (2771068) | 2771068..2771415 | - | 348 | WP_000612626.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| QMG87_RS14595 (2771412) | 2771412..2771816 | - | 405 | WP_000839179.1 | transposase | - |
| QMG87_RS14600 (2771896) | 2771896..2772246 | + | 351 | Protein_2866 | IrmA family protein | - |
| QMG87_RS14605 (2772325) | 2772325..2772558 | + | 234 | WP_001119729.1 | DUF905 family protein | - |
| QMG87_RS14610 (2772658) | 2772658..2773476 | + | 819 | WP_001234620.1 | DUF932 domain-containing protein | - |
| QMG87_RS14615 (2773531) | 2773531..2774016 | + | 486 | WP_000849582.1 | antirestriction protein | - |
| QMG87_RS14620 (2774032) | 2774032..2774508 | + | 477 | WP_001186725.1 | RadC family protein | - |
| QMG87_RS14625 (2774577) | 2774577..2774798 | + | 222 | WP_000692323.1 | DUF987 domain-containing protein | - |
| QMG87_RS14630 (2774961) | 2774961..2775329 | + | 369 | WP_001295723.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| QMG87_RS14635 (2775419) | 2775419..2775796 | + | 378 | WP_000854757.1 | TA system toxin CbtA family protein | Toxin |
| QMG87_RS14640 (2775793) | 2775793..2775942 | + | 150 | Protein_2874 | DUF5983 family protein | - |
| QMG87_RS14645 (2776042) | 2776042..2776122 | + | 81 | Protein_2875 | hypothetical protein | - |
| QMG87_RS14650 (2776938) | 2776938..2777309 | + | 372 | WP_001295631.1 | IS110 family transposase | - |
| QMG87_RS14655 (2777580) | 2777580..2777945 | + | 366 | WP_001282181.1 | EutP/PduV family microcompartment system protein | - |
| QMG87_RS14660 (2778046) | 2778046..2778375 | - | 330 | WP_000450409.1 | DUF496 family protein | - |
| QMG87_RS14665 (2778547) | 2778547..2779605 | - | 1059 | WP_001200883.1 | FUSC family protein | - |
| QMG87_RS14670 (2779803) | 2779803..2780276 | - | 474 | WP_001105384.1 | DNA gyrase inhibitor SbmC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14153.18 Da Isoelectric Point: 7.3249
>T43223 WP_000854757.1 NZ_AP027170:2775419-2775796 [Escherichia coli]
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
Download Length: 378 bp
>T43223 NZ_AP027170:2775419-2775796 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13592.40 Da Isoelectric Point: 6.6255
>AT43223 WP_001295723.1 NZ_AP027170:2774961-2775329 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT43223 NZ_AP027170:2774961-2775329 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
ACCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
ACCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A136X5A2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S1NM52 |