Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2518442..2518913 | Replicon | chromosome |
| Accession | NZ_AP027170 | ||
| Organism | Escherichia coli strain 20.1 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | QMG87_RS13310 | Protein ID | WP_001303511.1 |
| Coordinates | 2518635..2518913 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | QMG87_RS13305 | Protein ID | WP_001302048.1 |
| Coordinates | 2518442..2518633 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMG87_RS13255 (2513520) | 2513520..2513738 | - | 219 | WP_000683609.1 | DUF4014 family protein | - |
| QMG87_RS13260 (2513866) | 2513866..2514177 | - | 312 | WP_001289673.1 | hypothetical protein | - |
| QMG87_RS13265 (2514170) | 2514170..2514397 | - | 228 | WP_000699809.1 | hypothetical protein | - |
| QMG87_RS13270 (2514394) | 2514394..2514675 | - | 282 | WP_000603384.1 | DNA-binding protein | - |
| QMG87_RS13275 (2514708) | 2514708..2515469 | - | 762 | WP_000450872.1 | DUF1627 domain-containing protein | - |
| QMG87_RS13280 (2515495) | 2515495..2516236 | - | 742 | Protein_2610 | ATP-binding protein | - |
| QMG87_RS13285 (2516243) | 2516243..2517205 | - | 963 | WP_001444941.1 | helix-turn-helix domain-containing protein | - |
| QMG87_RS13290 (2517228) | 2517228..2517653 | - | 426 | WP_000693943.1 | toxin YdaT family protein | - |
| QMG87_RS13295 (2517650) | 2517650..2517952 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
| QMG87_RS13300 (2518050) | 2518050..2518421 | + | 372 | WP_001169687.1 | hypothetical protein | - |
| QMG87_RS13305 (2518442) | 2518442..2518633 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| QMG87_RS13310 (2518635) | 2518635..2518913 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| QMG87_RS13315 (2519200) | 2519200..2519352 | + | 153 | WP_001427316.1 | DUF1391 family protein | - |
| QMG87_RS13320 (2519773) | 2519773..2519994 | + | 222 | WP_000560218.1 | killing protein KilR | - |
| QMG87_RS13325 (2519994) | 2519994..2520164 | + | 171 | WP_001427414.1 | YdaE family protein | - |
| QMG87_RS13330 (2520238) | 2520238..2520513 | + | 276 | WP_001307773.1 | hypothetical protein | - |
| QMG87_RS13335 (2520612) | 2520612..2521517 | + | 906 | Protein_2621 | exonuclease VIII | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleG7' | 2462139..2567749 | 105610 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T43214 WP_001303511.1 NZ_AP027170:2518635-2518913 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T43214 NZ_AP027170:2518635-2518913 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT43214 WP_001302048.1 NZ_AP027170:2518442-2518633 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT43214 NZ_AP027170:2518442-2518633 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|