Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2183968..2184494 | Replicon | chromosome |
| Accession | NZ_AP027170 | ||
| Organism | Escherichia coli strain 20.1 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | QMG87_RS11495 | Protein ID | WP_000323025.1 |
| Coordinates | 2183968..2184255 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | QMG87_RS11500 | Protein ID | WP_000534858.1 |
| Coordinates | 2184255..2184494 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMG87_RS11445 (2178992) | 2178992..2179207 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| QMG87_RS11450 (2179427) | 2179427..2179597 | + | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| QMG87_RS11455 (2179961) | 2179961..2180176 | - | 216 | WP_000066483.1 | cold shock-like protein CspB | - |
| QMG87_RS11460 (2180477) | 2180477..2180689 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| QMG87_RS11465 (2180744) | 2180744..2180833 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| QMG87_RS11470 (2181111) | 2181111..2181863 | - | 753 | WP_001047133.1 | antitermination protein | - |
| QMG87_RS11475 (2181877) | 2181877..2182926 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| QMG87_RS11480 (2182928) | 2182928..2183206 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| QMG87_RS11485 (2183273) | 2183273..2183524 | - | 252 | WP_000980994.1 | protein Rem | - |
| QMG87_RS11490 (2183741) | 2183741..2183896 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| QMG87_RS11495 (2183968) | 2183968..2184255 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| QMG87_RS11500 (2184255) | 2184255..2184494 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| QMG87_RS11505 (2184519) | 2184519..2184824 | + | 306 | WP_001326990.1 | protein YdfV | - |
| QMG87_RS11510 (2185027) | 2185027..2185359 | + | 333 | WP_001317460.1 | FlxA-like family protein | - |
| QMG87_RS11515 (2185796) | 2185796..2185945 | - | 150 | WP_180302674.1 | protein YdfW | - |
| QMG87_RS11520 (2186018) | 2186018..2187115 | - | 1098 | Protein_2261 | ISNCY family transposase | - |
| QMG87_RS11525 (2187170) | 2187170..2187589 | - | 420 | WP_001151195.1 | DUF977 family protein | - |
| QMG87_RS11530 (2187630) | 2187630..2188595 | - | 966 | WP_000054507.1 | hypothetical protein | - |
| QMG87_RS11535 (2188576) | 2188576..2189097 | - | 522 | WP_000705349.1 | toxin YdaT family protein | - |
| QMG87_RS11540 (2189081) | 2189081..2189308 | - | 228 | WP_000476993.1 | Cro/CI family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2112255..2234695 | 122440 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T43213 WP_000323025.1 NZ_AP027170:c2184255-2183968 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T43213 NZ_AP027170:c2184255-2183968 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT43213 WP_000534858.1 NZ_AP027170:c2184494-2184255 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT43213 NZ_AP027170:c2184494-2184255 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|