Detailed information of TA system TA043203

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 1170117..1170595
• Replicon: chromosome
• Accession: NZ_AP027170
• Organism: Escherichia coli strain 20.1

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A891SFN9
• Locus tag: QMG87_RS05720
• Protein ID: WP_001303876.1
• Coordinates: 1170117..1170404 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: Q8XD67
• Locus tag: QMG87_RS05725
• Protein ID: WP_000536233.1
• Coordinates: 1170404..1170595 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMG87_RS05690 (1165340)	1165340..1167790	-	2451	WP_009448824.1	exonuclease	-
QMG87_RS05695 (1167884)	1167884..1168075	-	192	WP_001098307.1	DUF1482 family protein	-
QMG87_RS05700 (1168072)	1168072..1168260	-	189	WP_000413705.1	cell division inhibition protein DicB	-
QMG87_RS05705 (1168828)	1168828..1169037	+	210	WP_001133037.1	hypothetical protein	-
QMG87_RS05710 (1169038)	1169038..1169676	-	639	WP_000394543.1	hypothetical protein	-
QMG87_RS05715 (1169688)	1169688..1169840	-	153	WP_000379552.1	DUF1391 family protein	-
QMG87_RS05720 (1170117)	1170117..1170404	-	288	WP_001303876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
QMG87_RS05725 (1170404)	1170404..1170595	-	192	WP_000536233.1	hypothetical protein	Antitoxin
QMG87_RS05730 (1170623)	1170623..1171024	-	402	WP_000986592.1	helix-turn-helix domain-containing protein	-
QMG87_RS05735 (1171133)	1171133..1171405	+	273	WP_000887453.1	YdaS family helix-turn-helix protein	-
QMG87_RS05740 (1171389)	1171389..1171814	+	426	WP_000693855.1	toxin YdaT family protein	-
QMG87_RS05745 (1172021)	1172021..1172476	-	456	WP_000273724.1	hypothetical protein	-
QMG87_RS05750 (1172555)	1172555..1173670	+	1116	WP_001205820.1	hypothetical protein	-
QMG87_RS05755 (1173677)	1173677..1174417	+	741	WP_021498074.1	ATP-binding protein	-
QMG87_RS05760 (1174443)	1174443..1175213	+	771	WP_032324560.1	DUF1627 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1164033..1174417	10384

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10978.84 Da
• Isoelectric Point: 10.1360

>T43203 WP_001303876.1 NZ_AP027170:c1170404-1170117 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Nucleotide

• Length: 288 bp

>T43203 NZ_AP027170:c1170404-1170117 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7025.80 Da
• Isoelectric Point: 4.0270

>AT43203 WP_000536233.1 NZ_AP027170:c1170595-1170404 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Nucleotide

• Length: 192 bp

>AT43203 NZ_AP027170:c1170595-1170404 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA