Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5421276..5422108 Replicon chromosome
Accession NZ_AP027165
Organism Escherichia coli strain H19

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag QMG77_RS27390 Protein ID WP_000854753.1
Coordinates 5421734..5422108 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID V0ULY5
Locus tag QMG77_RS27385 Protein ID WP_001315620.1
Coordinates 5421276..5421644 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG77_RS27355 (5418112) 5418112..5418567 + 456 WP_000581504.1 IrmA family protein -
QMG77_RS27360 (5418646) 5418646..5418879 + 234 WP_001119729.1 DUF905 family protein -
QMG77_RS27365 (5418979) 5418979..5419797 + 819 WP_001234622.1 DUF932 domain-containing protein -
QMG77_RS27370 (5419852) 5419852..5420337 + 486 WP_000849588.1 antirestriction protein -
QMG77_RS27375 (5420353) 5420353..5420829 + 477 WP_001186774.1 RadC family protein -
QMG77_RS27380 (5420892) 5420892..5421113 + 222 WP_000692345.1 DUF987 domain-containing protein -
QMG77_RS27385 (5421276) 5421276..5421644 + 369 WP_001315620.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QMG77_RS27390 (5421734) 5421734..5422108 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
QMG77_RS27395 (5422105) 5422105..5422593 + 489 WP_000777547.1 DUF5983 family protein -
QMG77_RS27400 (5422605) 5422605..5422802 + 198 WP_000839281.1 DUF957 domain-containing protein -
QMG77_RS27405 (5422887) 5422887..5423036 + 150 Protein_5360 restriction endonuclease subunit M -
QMG77_RS27410 (5423804) 5423804..5423947 - 144 Protein_5361 HNH endonuclease -
QMG77_RS27415 (5424084) 5424084..5424734 + 651 WP_001037966.1 HNH endonuclease -
QMG77_RS27420 (5424742) 5424742..5425722 - 981 WP_000991415.1 sialate O-acetylesterase -
QMG77_RS27425 (5425787) 5425787..5426893 - 1107 WP_001341302.1 N-acetylneuraminate epimerase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T43192 WP_000854753.1 NZ_AP027165:5421734-5422108 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T43192 NZ_AP027165:5421734-5422108 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13474.20 Da        Isoelectric Point: 6.2050

>AT43192 WP_001315620.1 NZ_AP027165:5421276-5421644 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT43192 NZ_AP027165:5421276-5421644 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0


Antitoxin

Source ID Structure
AlphaFold DB V0ULY5

References