Detailed information of TA system TA043187

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3788183..3788837
• Replicon: chromosome
• Accession: NZ_AP027165
• Organism: Escherichia coli strain H19

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: S1EEB2
• Locus tag: QMG77_RS19475
• Protein ID: WP_000244777.1
• Coordinates: 3788183..3788590 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: QMG77_RS19480
• Protein ID: WP_000354043.1
• Coordinates: 3788571..3788837 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMG77_RS19455 (3784140)	3784140..3785873	-	1734	WP_000813220.1	single-stranded-DNA-specific exonuclease RecJ	-
QMG77_RS19460 (3785879)	3785879..3786589	-	711	WP_000715214.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
QMG77_RS19465 (3786614)	3786614..3787510	-	897	WP_000806638.1	site-specific tyrosine recombinase XerD	-
QMG77_RS19470 (3787622)	3787622..3788143	+	522	WP_001055874.1	flavodoxin FldB	-
QMG77_RS19475 (3788183)	3788183..3788590	-	408	WP_000244777.1	protein YgfX	Toxin
QMG77_RS19480 (3788571)	3788571..3788837	-	267	WP_000354043.1	FAD assembly factor SdhE	Antitoxin
QMG77_RS19485 (3789080)	3789080..3790060	+	981	WP_000886095.1	tRNA-modifying protein YgfZ	-
QMG77_RS19490 (3790256)	3790256..3790915	-	660	WP_000250274.1	hemolysin III family protein	-
QMG77_RS19495 (3791079)	3791079..3791390	-	312	WP_001182954.1	N(4)-acetylcytidine aminohydrolase	-
QMG77_RS19500 (3791435)	3791435..3792868	+	1434	WP_001341859.1	6-phospho-beta-glucosidase BglA	-
QMG77_RS19505 (3792925)	3792925..3793668	-	744	WP_000951964.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 16031.96 Da
• Isoelectric Point: 11.5202

>T43187 WP_000244777.1 NZ_AP027165:c3788590-3788183 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Nucleotide

• Length: 408 bp

>T43187 NZ_AP027165:c3788590-3788183 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10563.16 Da
• Isoelectric Point: 5.1599

>AT43187 WP_000354043.1 NZ_AP027165:c3788837-3788571 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDLDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT43187 NZ_AP027165:c3788837-3788571 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCTGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A7U9LFV7