Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2665188..2666023 | Replicon | chromosome |
| Accession | NZ_AP027165 | ||
| Organism | Escherichia coli strain H19 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A136X5A2 |
| Locus tag | QMG77_RS13855 | Protein ID | WP_000854757.1 |
| Coordinates | 2665646..2666023 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1NM52 |
| Locus tag | QMG77_RS13850 | Protein ID | WP_001295723.1 |
| Coordinates | 2665188..2665556 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMG77_RS13810 (2661295) | 2661295..2661642 | - | 348 | WP_000612626.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| QMG77_RS13815 (2661639) | 2661639..2662043 | - | 405 | WP_000839179.1 | transposase | - |
| QMG77_RS13820 (2662123) | 2662123..2662473 | + | 351 | Protein_2717 | IrmA family protein | - |
| QMG77_RS13825 (2662552) | 2662552..2662785 | + | 234 | WP_001119729.1 | DUF905 family protein | - |
| QMG77_RS13830 (2662885) | 2662885..2663703 | + | 819 | WP_001234620.1 | DUF932 domain-containing protein | - |
| QMG77_RS13835 (2663758) | 2663758..2664243 | + | 486 | WP_000849582.1 | antirestriction protein | - |
| QMG77_RS13840 (2664259) | 2664259..2664735 | + | 477 | WP_001186725.1 | RadC family protein | - |
| QMG77_RS13845 (2664804) | 2664804..2665025 | + | 222 | WP_000692323.1 | DUF987 domain-containing protein | - |
| QMG77_RS13850 (2665188) | 2665188..2665556 | + | 369 | WP_001295723.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| QMG77_RS13855 (2665646) | 2665646..2666023 | + | 378 | WP_000854757.1 | TA system toxin CbtA family protein | Toxin |
| QMG77_RS13860 (2666020) | 2666020..2666169 | + | 150 | Protein_2725 | DUF5983 family protein | - |
| QMG77_RS13865 (2666269) | 2666269..2666349 | + | 81 | Protein_2726 | hypothetical protein | - |
| QMG77_RS13870 (2667165) | 2667165..2667536 | + | 372 | WP_001295631.1 | IS110 family transposase | - |
| QMG77_RS13875 (2667807) | 2667807..2668172 | + | 366 | WP_001282181.1 | EutP/PduV family microcompartment system protein | - |
| QMG77_RS13880 (2668273) | 2668273..2668602 | - | 330 | WP_000450409.1 | DUF496 family protein | - |
| QMG77_RS13885 (2668774) | 2668774..2669832 | - | 1059 | WP_001200883.1 | FUSC family protein | - |
| QMG77_RS13890 (2670030) | 2670030..2670503 | - | 474 | WP_001105384.1 | DNA gyrase inhibitor SbmC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14153.18 Da Isoelectric Point: 7.3249
>T43182 WP_000854757.1 NZ_AP027165:2665646-2666023 [Escherichia coli]
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
Download Length: 378 bp
>T43182 NZ_AP027165:2665646-2666023 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13592.40 Da Isoelectric Point: 6.6255
>AT43182 WP_001295723.1 NZ_AP027165:2665188-2665556 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT43182 NZ_AP027165:2665188-2665556 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
ACCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
ACCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A136X5A2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S1NM52 |