Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2408669..2409140 | Replicon | chromosome |
| Accession | NZ_AP027165 | ||
| Organism | Escherichia coli strain H19 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | QMG77_RS12530 | Protein ID | WP_001303511.1 |
| Coordinates | 2408862..2409140 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | QMG77_RS12525 | Protein ID | WP_001302048.1 |
| Coordinates | 2408669..2408860 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMG77_RS12475 (2403747) | 2403747..2403965 | - | 219 | WP_000683609.1 | DUF4014 family protein | - |
| QMG77_RS12480 (2404093) | 2404093..2404404 | - | 312 | WP_001289673.1 | hypothetical protein | - |
| QMG77_RS12485 (2404397) | 2404397..2404624 | - | 228 | WP_000699809.1 | hypothetical protein | - |
| QMG77_RS12490 (2404621) | 2404621..2404902 | - | 282 | WP_000603384.1 | DNA-binding protein | - |
| QMG77_RS12495 (2404935) | 2404935..2405696 | - | 762 | WP_000450872.1 | DUF1627 domain-containing protein | - |
| QMG77_RS12500 (2405722) | 2405722..2406463 | - | 742 | Protein_2461 | ATP-binding protein | - |
| QMG77_RS12505 (2406470) | 2406470..2407432 | - | 963 | WP_001444941.1 | helix-turn-helix domain-containing protein | - |
| QMG77_RS12510 (2407455) | 2407455..2407880 | - | 426 | WP_000693943.1 | toxin YdaT family protein | - |
| QMG77_RS12515 (2407877) | 2407877..2408179 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
| QMG77_RS12520 (2408277) | 2408277..2408648 | + | 372 | WP_001169687.1 | hypothetical protein | - |
| QMG77_RS12525 (2408669) | 2408669..2408860 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| QMG77_RS12530 (2408862) | 2408862..2409140 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| QMG77_RS12535 (2409427) | 2409427..2409579 | + | 153 | WP_001427316.1 | DUF1391 family protein | - |
| QMG77_RS12540 (2410000) | 2410000..2410221 | + | 222 | WP_000560218.1 | killing protein KilR | - |
| QMG77_RS12545 (2410221) | 2410221..2410391 | + | 171 | WP_001427414.1 | YdaE family protein | - |
| QMG77_RS12550 (2410465) | 2410465..2410740 | + | 276 | WP_001307773.1 | hypothetical protein | - |
| QMG77_RS12555 (2410839) | 2410839..2411744 | + | 906 | Protein_2472 | exonuclease VIII | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleG7' | 2359974..2423288 | 63314 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T43173 WP_001303511.1 NZ_AP027165:2408862-2409140 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T43173 NZ_AP027165:2408862-2409140 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT43173 WP_001302048.1 NZ_AP027165:2408669-2408860 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT43173 NZ_AP027165:2408669-2408860 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|