Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2073973..2074499 | Replicon | chromosome |
| Accession | NZ_AP027165 | ||
| Organism | Escherichia coli strain H19 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | QMG77_RS10705 | Protein ID | WP_000323025.1 |
| Coordinates | 2073973..2074260 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | QMG77_RS10710 | Protein ID | WP_000534858.1 |
| Coordinates | 2074260..2074499 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMG77_RS10655 (2068997) | 2068997..2069212 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| QMG77_RS10660 (2069432) | 2069432..2069602 | + | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| QMG77_RS10665 (2069966) | 2069966..2070181 | - | 216 | WP_000066483.1 | cold shock-like protein CspB | - |
| QMG77_RS10670 (2070482) | 2070482..2070694 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| QMG77_RS10675 (2070749) | 2070749..2070838 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| QMG77_RS10680 (2071116) | 2071116..2071868 | - | 753 | WP_001047133.1 | antitermination protein | - |
| QMG77_RS10685 (2071882) | 2071882..2072931 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| QMG77_RS10690 (2072933) | 2072933..2073211 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| QMG77_RS10695 (2073278) | 2073278..2073529 | - | 252 | WP_000980994.1 | protein Rem | - |
| QMG77_RS10700 (2073746) | 2073746..2073901 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| QMG77_RS10705 (2073973) | 2073973..2074260 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| QMG77_RS10710 (2074260) | 2074260..2074499 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| QMG77_RS10715 (2074524) | 2074524..2074829 | + | 306 | WP_001326990.1 | protein YdfV | - |
| QMG77_RS10720 (2075032) | 2075032..2075364 | + | 333 | WP_001317460.1 | FlxA-like family protein | - |
| QMG77_RS10725 (2075801) | 2075801..2075950 | - | 150 | WP_180302674.1 | protein YdfW | - |
| QMG77_RS10730 (2076023) | 2076023..2077120 | - | 1098 | Protein_2110 | ISNCY family transposase | - |
| QMG77_RS10735 (2077175) | 2077175..2077594 | - | 420 | WP_001151195.1 | DUF977 family protein | - |
| QMG77_RS10740 (2077635) | 2077635..2078600 | - | 966 | WP_000054507.1 | hypothetical protein | - |
| QMG77_RS10745 (2078581) | 2078581..2079102 | - | 522 | WP_000705349.1 | toxin YdaT family protein | - |
| QMG77_RS10750 (2079086) | 2079086..2079313 | - | 228 | WP_000476993.1 | Cro/CI family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2038647..2089704 | 51057 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T43172 WP_000323025.1 NZ_AP027165:c2074260-2073973 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T43172 NZ_AP027165:c2074260-2073973 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT43172 WP_000534858.1 NZ_AP027165:c2074499-2074260 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT43172 NZ_AP027165:c2074499-2074260 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|