Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1536208..1537003 Replicon chromosome
Accession NZ_AP027165
Organism Escherichia coli strain H19

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag QMG77_RS07860 Protein ID WP_000854914.1
Coordinates 1536629..1537003 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9LM11
Locus tag QMG77_RS07855 Protein ID WP_001280953.1
Coordinates 1536208..1536582 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG77_RS07825 (1531563) 1531563..1532468 + 906 WP_000203541.1 diguanylate cyclase regulator RdcB family protein -
QMG77_RS07830 (1532465) 1532465..1533535 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
QMG77_RS07835 (1533875) 1533875..1534693 + 819 WP_001234682.1 DUF932 domain-containing protein -
QMG77_RS07840 (1534784) 1534784..1535269 + 486 WP_000214398.1 antirestriction protein -
QMG77_RS07845 (1535285) 1535285..1535761 + 477 WP_001186738.1 RadC family protein -
QMG77_RS07850 (1535824) 1535824..1536045 + 222 WP_000692323.1 DUF987 domain-containing protein -
QMG77_RS07855 (1536208) 1536208..1536582 + 375 WP_001280953.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QMG77_RS07860 (1536629) 1536629..1537003 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
QMG77_RS07865 (1537000) 1537000..1537491 + 492 WP_000976857.1 DUF5983 family protein -
QMG77_RS07870 (1537503) 1537503..1537700 + 198 WP_000839282.1 DUF957 domain-containing protein -
QMG77_RS07875 (1537785) 1537785..1538627 + 843 WP_001280481.1 DUF4942 domain-containing protein -
QMG77_RS07885 (1539098) 1539098..1540036 + 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
QMG77_RS07890 (1540091) 1540091..1540828 + 738 WP_000283664.1 zinc-binding phosphatase -
QMG77_RS07895 (1540852) 1540852..1541406 + 555 WP_001001902.1 molecular chaperone YcdY -
QMG77_RS07900 (1541508) 1541508..1541999 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 1524466..1547564 23098


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T43165 WP_000854914.1 NZ_AP027165:1536629-1537003 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T43165 NZ_AP027165:1536629-1537003 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13734.56 Da        Isoelectric Point: 6.6249

>AT43165 WP_001280953.1 NZ_AP027165:1536208-1536582 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPALATTS

Download         Length: 375 bp

>AT43165 NZ_AP027165:1536208-1536582 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACTCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LM11

References