Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-Phd |
| Location | 64761..65362 | Replicon | plasmid pO26_EH031_1 |
| Accession | NZ_AP027163 | ||
| Organism | Escherichia coli strain EH031 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | U9YA20 |
| Locus tag | QMG85_RS29515 | Protein ID | WP_001216045.1 |
| Coordinates | 64761..65141 (-) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | U9YQH9 |
| Locus tag | QMG85_RS29520 | Protein ID | WP_001190712.1 |
| Coordinates | 65141..65362 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMG85_RS29485 | 59888..60118 | - | 231 | Protein_63 | ash family protein | - |
| QMG85_RS29490 (BEL031_p1_061) | 60202..61686 | - | 1485 | WP_000124159.1 | hypothetical protein | - |
| QMG85_RS29495 (BEL031_p1_062) | 61686..62879 | - | 1194 | WP_023442315.1 | hypothetical protein | - |
| QMG85_RS29500 (BEL031_p1_063) | 62965..63417 | - | 453 | WP_001326849.1 | late promoter-activating protein | - |
| QMG85_RS29505 (BEL031_p1_064) | 63506..64549 | - | 1044 | WP_000648833.1 | DUF968 domain-containing protein | - |
| QMG85_RS29510 (BEL031_p1_065) | 64577..64756 | - | 180 | WP_000113018.1 | hypothetical protein | - |
| QMG85_RS29515 (BEL031_p1_066) | 64761..65141 | - | 381 | WP_001216045.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| QMG85_RS29520 (BEL031_p1_067) | 65141..65362 | - | 222 | WP_001190712.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| QMG85_RS29525 (BEL031_p1_068) | 65435..65824 | - | 390 | WP_000506730.1 | S24 family peptidase | - |
| QMG85_RS29530 (BEL031_p1_069) | 65946..66224 | - | 279 | WP_136748066.1 | hypothetical protein | - |
| QMG85_RS29535 (BEL031_p1_071) | 66497..67177 | - | 681 | WP_044862031.1 | hypothetical protein | - |
| QMG85_RS29540 (BEL031_p1_072) | 67159..67533 | - | 375 | WP_000988656.1 | hypothetical protein | - |
| QMG85_RS29545 (BEL031_p1_073) | 67540..67833 | - | 294 | WP_000269002.1 | hypothetical protein | - |
| QMG85_RS29550 (BEL031_p1_075) | 68012..68245 | - | 234 | WP_000517421.1 | hypothetical protein | - |
| QMG85_RS29555 (BEL031_p1_076) | 68328..69026 | - | 699 | WP_044862032.1 | DUF551 domain-containing protein | - |
| QMG85_RS29560 (BEL031_p1_077) | 69227..69439 | - | 213 | WP_000063625.1 | hypothetical protein | - |
| QMG85_RS29565 (BEL031_p1_078) | 69488..69844 | - | 357 | WP_000403779.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..97108 | 97108 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 13588.29 Da Isoelectric Point: 5.1514
>T43159 WP_001216045.1 NZ_AP027163:c65141-64761 [Escherichia coli]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE
Download Length: 381 bp
>T43159 NZ_AP027163:c65141-64761 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCTGGCATGTC
AGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGCGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACTGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCGGAGTAG
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCTGGCATGTC
AGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGCGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACTGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCGGAGTAG
Antitoxin
Download Length: 74 a.a. Molecular weight: 8133.10 Da Isoelectric Point: 4.7708
>AT43159 WP_001190712.1 NZ_AP027163:c65362-65141 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
Download Length: 222 bp
>AT43159 NZ_AP027163:c65362-65141 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CLP7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CJB6 |