Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2859882..2860717 Replicon chromosome
Accession NZ_AP027162
Organism Escherichia coli strain EH031

Toxin (Protein)


Gene name yeeV Uniprot ID A0A136X5A2
Locus tag QMG85_RS15040 Protein ID WP_000854757.1
Coordinates 2860340..2860717 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag QMG85_RS15035 Protein ID WP_001295723.1
Coordinates 2859882..2860250 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG85_RS14995 (2855989) 2855989..2856336 - 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
QMG85_RS15000 (2856333) 2856333..2856737 - 405 WP_000839179.1 transposase -
QMG85_RS15005 (2856817) 2856817..2857167 + 351 Protein_2949 IrmA family protein -
QMG85_RS15010 (2857246) 2857246..2857479 + 234 WP_001119729.1 DUF905 family protein -
QMG85_RS15015 (2857579) 2857579..2858397 + 819 WP_001234620.1 DUF932 domain-containing protein -
QMG85_RS15020 (2858452) 2858452..2858937 + 486 WP_000849582.1 antirestriction protein -
QMG85_RS15025 (2858953) 2858953..2859429 + 477 WP_001186725.1 RadC family protein -
QMG85_RS15030 (2859498) 2859498..2859719 + 222 WP_099356098.1 DUF987 domain-containing protein -
QMG85_RS15035 (2859882) 2859882..2860250 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QMG85_RS15040 (2860340) 2860340..2860717 + 378 WP_000854757.1 TA system toxin CbtA family protein Toxin
QMG85_RS15045 (2860714) 2860714..2860863 + 150 Protein_2957 DUF5983 family protein -
QMG85_RS15050 (2860963) 2860963..2861043 + 81 Protein_2958 hypothetical protein -
QMG85_RS15055 (2861859) 2861859..2862230 + 372 WP_001295631.1 IS110 family transposase -
QMG85_RS15060 (2862501) 2862501..2862866 + 366 WP_001282181.1 EutP/PduV family microcompartment system protein -
QMG85_RS15065 (2862967) 2862967..2863296 - 330 WP_000450409.1 DUF496 family protein -
QMG85_RS15070 (2863468) 2863468..2864526 - 1059 WP_001200887.1 FUSC family protein -
QMG85_RS15075 (2864724) 2864724..2865197 - 474 WP_001105384.1 DNA gyrase inhibitor SbmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14153.18 Da        Isoelectric Point: 7.3249

>T43146 WP_000854757.1 NZ_AP027162:2860340-2860717 [Escherichia coli]
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T43146 NZ_AP027162:2860340-2860717 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT43146 WP_001295723.1 NZ_AP027162:2859882-2860250 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT43146 NZ_AP027162:2859882-2860250 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A136X5A2

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References