Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2603345..2603816 | Replicon | chromosome |
| Accession | NZ_AP027162 | ||
| Organism | Escherichia coli strain EH031 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | QMG85_RS13710 | Protein ID | WP_001303511.1 |
| Coordinates | 2603538..2603816 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | QMG85_RS13705 | Protein ID | WP_001302048.1 |
| Coordinates | 2603345..2603536 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMG85_RS13655 (2598423) | 2598423..2598641 | - | 219 | WP_000683609.1 | DUF4014 family protein | - |
| QMG85_RS13660 (2598769) | 2598769..2599080 | - | 312 | WP_001289673.1 | hypothetical protein | - |
| QMG85_RS13665 (2599073) | 2599073..2599300 | - | 228 | WP_000699809.1 | hypothetical protein | - |
| QMG85_RS13670 (2599297) | 2599297..2599578 | - | 282 | WP_000603384.1 | DNA-binding protein | - |
| QMG85_RS13675 (2599611) | 2599611..2600372 | - | 762 | WP_000450872.1 | DUF1627 domain-containing protein | - |
| QMG85_RS13680 (2600398) | 2600398..2601139 | - | 742 | Protein_2692 | ATP-binding protein | - |
| QMG85_RS13685 (2601146) | 2601146..2602108 | - | 963 | WP_001444941.1 | helix-turn-helix domain-containing protein | - |
| QMG85_RS13690 (2602131) | 2602131..2602556 | - | 426 | WP_000693943.1 | toxin YdaT family protein | - |
| QMG85_RS13695 (2602553) | 2602553..2602855 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
| QMG85_RS13700 (2602953) | 2602953..2603324 | + | 372 | WP_001169687.1 | hypothetical protein | - |
| QMG85_RS13705 (2603345) | 2603345..2603536 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| QMG85_RS13710 (2603538) | 2603538..2603816 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| QMG85_RS13715 (2604103) | 2604103..2604255 | + | 153 | WP_001427316.1 | DUF1391 family protein | - |
| QMG85_RS13720 (2604676) | 2604676..2604897 | + | 222 | WP_000560218.1 | killing protein KilR | - |
| QMG85_RS13725 (2604897) | 2604897..2605067 | + | 171 | WP_001427414.1 | YdaE family protein | - |
| QMG85_RS13730 (2605141) | 2605141..2605416 | + | 276 | WP_001307773.1 | hypothetical protein | - |
| QMG85_RS13735 (2605515) | 2605515..2608166 | + | 2652 | WP_000105101.1 | exodeoxyribonuclease VIII | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleG7' | 2555895..2616698 | 60803 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T43137 WP_001303511.1 NZ_AP027162:2603538-2603816 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T43137 NZ_AP027162:2603538-2603816 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT43137 WP_001302048.1 NZ_AP027162:2603345-2603536 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT43137 NZ_AP027162:2603345-2603536 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|