Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2285189..2285715 | Replicon | chromosome |
| Accession | NZ_AP027162 | ||
| Organism | Escherichia coli strain EH031 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | QMG85_RS12020 | Protein ID | WP_000323025.1 |
| Coordinates | 2285189..2285476 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | QMG85_RS12025 | Protein ID | WP_000534858.1 |
| Coordinates | 2285476..2285715 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMG85_RS11970 (2280213) | 2280213..2280428 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| QMG85_RS11975 (2280648) | 2280648..2280818 | + | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| QMG85_RS11980 (2281182) | 2281182..2281397 | - | 216 | WP_000066483.1 | cold shock-like protein CspB | - |
| QMG85_RS11985 (2281698) | 2281698..2281910 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| QMG85_RS11990 (2281965) | 2281965..2282054 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| QMG85_RS11995 (2282332) | 2282332..2283084 | - | 753 | WP_001047133.1 | antitermination protein | - |
| QMG85_RS12000 (2283098) | 2283098..2284147 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| QMG85_RS12005 (2284149) | 2284149..2284427 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| QMG85_RS12010 (2284494) | 2284494..2284745 | - | 252 | WP_000980994.1 | protein Rem | - |
| QMG85_RS12015 (2284962) | 2284962..2285117 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| QMG85_RS12020 (2285189) | 2285189..2285476 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| QMG85_RS12025 (2285476) | 2285476..2285715 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| QMG85_RS12030 (2285740) | 2285740..2286045 | + | 306 | WP_001326990.1 | protein YdfV | - |
| QMG85_RS12035 (2286248) | 2286248..2286580 | + | 333 | WP_001317460.1 | FlxA-like family protein | - |
| QMG85_RS12040 (2287017) | 2287017..2287166 | - | 150 | WP_180302674.1 | protein YdfW | - |
| QMG85_RS12045 (2287239) | 2287239..2288336 | - | 1098 | Protein_2368 | ISNCY family transposase | - |
| QMG85_RS12050 (2288391) | 2288391..2288810 | - | 420 | WP_001151195.1 | DUF977 family protein | - |
| QMG85_RS12055 (2288851) | 2288851..2289816 | - | 966 | WP_000054507.1 | hypothetical protein | - |
| QMG85_RS12060 (2289797) | 2289797..2290318 | - | 522 | WP_000705349.1 | toxin YdaT family protein | - |
| QMG85_RS12065 (2290302) | 2290302..2290529 | - | 228 | WP_000476993.1 | Cro/CI family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2249863..2301110 | 51247 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T43136 WP_000323025.1 NZ_AP027162:c2285476-2285189 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T43136 NZ_AP027162:c2285476-2285189 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT43136 WP_000534858.1 NZ_AP027162:c2285715-2285476 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT43136 NZ_AP027162:c2285715-2285476 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|