Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2112541..2113179 Replicon chromosome
Accession NZ_AP027162
Organism Escherichia coli strain EH031

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QMG85_RS11195 Protein ID WP_000813794.1
Coordinates 2112541..2112717 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QMG85_RS11200 Protein ID WP_001270286.1
Coordinates 2112763..2113179 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG85_RS11175 (2108160) 2108160..2109374 - 1215 WP_001307190.1 BenE family transporter YdcO -
QMG85_RS11180 (2109427) 2109427..2109963 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
QMG85_RS11185 (2110036) 2110036..2111997 + 1962 WP_099356044.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QMG85_RS11190 (2112089) 2112089..2112319 - 231 WP_000494244.1 YncJ family protein -
QMG85_RS11195 (2112541) 2112541..2112717 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QMG85_RS11200 (2112763) 2112763..2113179 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QMG85_RS11205 (2113258) 2113258..2114663 + 1406 Protein_2200 PLP-dependent aminotransferase family protein -
QMG85_RS11210 (2114908) 2114908..2116053 + 1146 WP_000047456.1 ABC transporter substrate-binding protein -
QMG85_RS11215 (2116071) 2116071..2117084 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
QMG85_RS11220 (2117085) 2117085..2118026 + 942 WP_001251332.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2106972..2108120 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T43134 WP_000813794.1 NZ_AP027162:2112541-2112717 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T43134 NZ_AP027162:2112541-2112717 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT43134 WP_001270286.1 NZ_AP027162:2112763-2113179 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT43134 NZ_AP027162:2112763-2113179 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References