Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-YafN |
Location | 1822..2357 | Replicon | plasmid pO26_2313_1 |
Accession | NZ_AP027160 | ||
Organism | Escherichia coli strain 2313 |
Toxin (Protein)
Gene name | relE | Uniprot ID | T2HS21 |
Locus tag | QMG94_RS29065 | Protein ID | WP_000222775.1 |
Coordinates | 2070..2357 (+) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | T2HSA2 |
Locus tag | QMG94_RS29060 | Protein ID | WP_001139207.1 |
Coordinates | 1822..2073 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QMG94_RS29050 (T2313_p1_001) | 1..873 | + | 873 | WP_000729440.1 | incFII family plasmid replication initiator RepA | - |
QMG94_RS29055 | 1568..1735 | + | 168 | WP_000841010.1 | hypothetical protein | - |
QMG94_RS29060 (T2313_p1_002) | 1822..2073 | + | 252 | WP_001139207.1 | plasmid stabilization protein | Antitoxin |
QMG94_RS29065 (T2313_p1_003) | 2070..2357 | + | 288 | WP_000222775.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
QMG94_RS29070 (T2313_p1_004) | 2367..2912 | + | 546 | WP_000926984.1 | hypothetical protein | - |
QMG94_RS29075 (T2313_p1_007) | 3564..4166 | - | 603 | WP_000517694.1 | ProQ/FINO family protein | - |
QMG94_RS29080 (T2313_p1_008) | 4520..4759 | + | 240 | Protein_6 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | tet(A) | - | 1..113641 | 113641 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11142.17 Da Isoelectric Point: 10.6261
>T43120 WP_000222775.1 NZ_AP027160:2070-2357 [Escherichia coli]
MTYTVKFRDDALREWLKLDKSVQQQFAKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSHVYNLASERMR
MTYTVKFRDDALREWLKLDKSVQQQFAKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSHVYNLASERMR
Download Length: 288 bp
>T43120 NZ_AP027160:2070-2357 [Escherichia coli]
ATGACTTATACGGTTAAATTCAGGGATGATGCCCTCAGGGAATGGCTGAAACTGGATAAATCCGTTCAACAACAGTTCGC
AAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCTTCAGCAAAACTACGAGGATTAAAAGATTGCTACAAAATAA
AACTTCGCGCATCAGGTTTTCGTCTGGTCTATCAGGTGATTGATGACATGTTAATTATTGCGGTTGTCGCAGTAGGTAAA
CGTGAACGTAGTCATGTTTACAATCTCGCCAGCGAGAGAATGAGATAG
ATGACTTATACGGTTAAATTCAGGGATGATGCCCTCAGGGAATGGCTGAAACTGGATAAATCCGTTCAACAACAGTTCGC
AAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCTTCAGCAAAACTACGAGGATTAAAAGATTGCTACAAAATAA
AACTTCGCGCATCAGGTTTTCGTCTGGTCTATCAGGTGATTGATGACATGTTAATTATTGCGGTTGTCGCAGTAGGTAAA
CGTGAACGTAGTCATGTTTACAATCTCGCCAGCGAGAGAATGAGATAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9216.45 Da Isoelectric Point: 4.0927
>AT43120 WP_001139207.1 NZ_AP027160:1822-2073 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDAMDDQELVKLVTERSNQPLHDVDLD
SYL
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDAMDDQELVKLVTERSNQPLHDVDLD
SYL
Download Length: 252 bp
>AT43120 NZ_AP027160:1822-2073 [Escherichia coli]
ATGCCCAGTATCATTTTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCAATGGCGACAGTCAGTGCCGG
AGAGGGGTATCCTGTTGCCATTCTTAACCGGAATCAGCCTGCATTCTACTGTGTTCCTGCTGAATTGTATGAAAGGATGC
TTGATGCTATGGATGACCAGGAGCTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTACATGATGTGGACCTGGAT
AGTTATTTATGA
ATGCCCAGTATCATTTTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCAATGGCGACAGTCAGTGCCGG
AGAGGGGTATCCTGTTGCCATTCTTAACCGGAATCAGCCTGCATTCTACTGTGTTCCTGCTGAATTGTATGAAAGGATGC
TTGATGCTATGGATGACCAGGAGCTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTACATGATGTGGACCTGGAT
AGTTATTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | T2HS21 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A754EQ65 |