Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 5487437..5488032 Replicon chromosome
Accession NZ_AP027159
Organism Escherichia coli strain 2313

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag QMG94_RS27940 Protein ID WP_000239579.1
Coordinates 5487682..5488032 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QMG94_RS27935 Protein ID WP_001223208.1
Coordinates 5487437..5487688 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG94_RS27925 (5483102) 5483102..5486881 + 3780 WP_000060926.1 autotransporter assembly complex protein TamB -
QMG94_RS27930 (5486884) 5486884..5487225 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QMG94_RS27935 (5487437) 5487437..5487688 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QMG94_RS27940 (5487682) 5487682..5488032 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
QMG94_RS27945 (5488112) 5488112..5488642 - 531 WP_000055075.1 inorganic diphosphatase -
QMG94_RS27950 (5488952) 5488952..5489908 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QMG94_RS27955 (5490048) 5490048..5491550 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
QMG94_RS27960 (5491564) 5491564..5492586 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T43116 WP_000239579.1 NZ_AP027159:5487682-5488032 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T43116 NZ_AP027159:5487682-5488032 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT43116 WP_001223208.1 NZ_AP027159:5487437-5487688 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT43116 NZ_AP027159:5487437-5487688 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References