Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 1765079..1765550 | Replicon | chromosome |
| Accession | NZ_AP027159 | ||
| Organism | Escherichia coli strain 2313 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | QMG94_RS09005 | Protein ID | WP_001303511.1 |
| Coordinates | 1765079..1765357 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | QMG94_RS09010 | Protein ID | WP_001302048.1 |
| Coordinates | 1765359..1765550 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMG94_RS08980 (1760729) | 1760729..1763380 | - | 2652 | WP_000105101.1 | exodeoxyribonuclease VIII | - |
| QMG94_RS08985 (1763479) | 1763479..1763754 | - | 276 | WP_001307773.1 | hypothetical protein | - |
| QMG94_RS08990 (1763828) | 1763828..1763998 | - | 171 | WP_001427414.1 | YdaE family protein | - |
| QMG94_RS08995 (1763998) | 1763998..1764219 | - | 222 | WP_000560218.1 | killing protein KilR | - |
| QMG94_RS09000 (1764640) | 1764640..1764792 | - | 153 | WP_001427316.1 | DUF1391 family protein | - |
| QMG94_RS09005 (1765079) | 1765079..1765357 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| QMG94_RS09010 (1765359) | 1765359..1765550 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| QMG94_RS09015 (1765571) | 1765571..1765942 | - | 372 | WP_001169687.1 | hypothetical protein | - |
| QMG94_RS09020 (1766041) | 1766041..1766343 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
| QMG94_RS09025 (1766340) | 1766340..1766765 | + | 426 | WP_000693943.1 | toxin YdaT family protein | - |
| QMG94_RS09030 (1766788) | 1766788..1767750 | + | 963 | WP_001444941.1 | helix-turn-helix domain-containing protein | - |
| QMG94_RS09035 (1767757) | 1767757..1768498 | + | 742 | Protein_1764 | ATP-binding protein | - |
| QMG94_RS09040 (1768524) | 1768524..1769285 | + | 762 | WP_000450872.1 | DUF1627 domain-containing protein | - |
| QMG94_RS09045 (1769318) | 1769318..1769599 | + | 282 | WP_000603384.1 | DNA-binding protein | - |
| QMG94_RS09050 (1769596) | 1769596..1769823 | + | 228 | WP_000699809.1 | hypothetical protein | - |
| QMG94_RS09055 (1769816) | 1769816..1770127 | + | 312 | WP_001289673.1 | hypothetical protein | - |
| QMG94_RS09060 (1770255) | 1770255..1770473 | + | 219 | WP_000683609.1 | DUF4014 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleC | 1752198..1815333 | 63135 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T43105 WP_001303511.1 NZ_AP027159:c1765357-1765079 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T43105 NZ_AP027159:c1765357-1765079 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT43105 WP_001302048.1 NZ_AP027159:c1765550-1765359 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT43105 NZ_AP027159:c1765550-1765359 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|