Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1546795..1547630 | Replicon | chromosome |
| Accession | NZ_AP027159 | ||
| Organism | Escherichia coli strain 2313 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A136X5A2 |
| Locus tag | QMG94_RS07930 | Protein ID | WP_000854757.1 |
| Coordinates | 1546795..1547172 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1NM52 |
| Locus tag | QMG94_RS07935 | Protein ID | WP_001295723.1 |
| Coordinates | 1547262..1547630 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMG94_RS07895 (1542315) | 1542315..1542788 | + | 474 | WP_001105384.1 | DNA gyrase inhibitor SbmC | - |
| QMG94_RS07900 (1542986) | 1542986..1544044 | + | 1059 | WP_001200887.1 | FUSC family protein | - |
| QMG94_RS07905 (1544216) | 1544216..1544545 | + | 330 | WP_000450409.1 | DUF496 family protein | - |
| QMG94_RS07910 (1544646) | 1544646..1545011 | - | 366 | WP_001282181.1 | EutP/PduV family microcompartment system protein | - |
| QMG94_RS07915 (1545282) | 1545282..1545653 | - | 372 | WP_001295631.1 | IS110 family transposase | - |
| QMG94_RS07920 (1546469) | 1546469..1546549 | - | 81 | Protein_1549 | hypothetical protein | - |
| QMG94_RS07925 (1546649) | 1546649..1546798 | - | 150 | Protein_1550 | DUF5983 family protein | - |
| QMG94_RS07930 (1546795) | 1546795..1547172 | - | 378 | WP_000854757.1 | TA system toxin CbtA family protein | Toxin |
| QMG94_RS07935 (1547262) | 1547262..1547630 | - | 369 | WP_001295723.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| QMG94_RS07940 (1547793) | 1547793..1548014 | - | 222 | WP_000692323.1 | DUF987 domain-containing protein | - |
| QMG94_RS07945 (1548083) | 1548083..1548559 | - | 477 | WP_001186725.1 | RadC family protein | - |
| QMG94_RS07950 (1548575) | 1548575..1549060 | - | 486 | WP_000849582.1 | antirestriction protein | - |
| QMG94_RS07955 (1549115) | 1549115..1549933 | - | 819 | WP_001234620.1 | DUF932 domain-containing protein | - |
| QMG94_RS07960 (1550033) | 1550033..1550266 | - | 234 | WP_001119729.1 | DUF905 family protein | - |
| QMG94_RS07965 (1550345) | 1550345..1550695 | - | 351 | Protein_1558 | IrmA family protein | - |
| QMG94_RS07970 (1550775) | 1550775..1551179 | + | 405 | WP_000839179.1 | transposase | - |
| QMG94_RS07975 (1551176) | 1551176..1551523 | + | 348 | WP_000612626.1 | IS66 family insertion sequence element accessory protein TnpB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14153.18 Da Isoelectric Point: 7.3249
>T43092 WP_000854757.1 NZ_AP027159:c1547172-1546795 [Escherichia coli]
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
Download Length: 378 bp
>T43092 NZ_AP027159:c1547172-1546795 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13592.40 Da Isoelectric Point: 6.6255
>AT43092 WP_001295723.1 NZ_AP027159:c1547630-1547262 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT43092 NZ_AP027159:c1547630-1547262 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A136X5A2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S1NM52 |