Detailed information of TA system TA043091

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 1497651..1498129
• Replicon: chromosome
• Accession: NZ_AP027159
• Organism: Escherichia coli strain 2313

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A891SFN9
• Locus tag: QMG94_RS07600
• Protein ID: WP_001303876.1
• Coordinates: 1497651..1497938 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: Q8XD67
• Locus tag: QMG94_RS07605
• Protein ID: WP_000536233.1
• Coordinates: 1497938..1498129 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMG94_RS07565 (1492801)	1492801..1495272	-	2472	WP_032278809.1	exonuclease	-
QMG94_RS07570 (1495366)	1495366..1495557	-	192	WP_001098307.1	DUF1482 family protein	-
QMG94_RS07575 (1495554)	1495554..1495742	-	189	WP_000413705.1	cell division inhibition protein DicB	-
QMG94_RS07580 (1496316)	1496316..1496501	+	186	WP_001133046.1	hypothetical protein	-
QMG94_RS07585 (1496688)	1496688..1497077	-	390	WP_000394511.1	hypothetical protein	-
QMG94_RS07590 (1497089)	1497089..1497217	-	129	WP_000344963.1	protein YdfB	-
QMG94_RS07595 (1497219)	1497219..1497374	-	156	WP_000379575.1	DUF1391 family protein	-
QMG94_RS07600 (1497651)	1497651..1497938	-	288	WP_001303876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
QMG94_RS07605 (1497938)	1497938..1498129	-	192	WP_000536233.1	hypothetical protein	Antitoxin
QMG94_RS07610 (1498157)	1498157..1498558	-	402	WP_000986592.1	helix-turn-helix domain-containing protein	-
QMG94_RS07615 (1498667)	1498667..1498939	+	273	WP_000887453.1	YdaS family helix-turn-helix protein	-
QMG94_RS07620 (1498923)	1498923..1499348	+	426	WP_000693855.1	toxin YdaT family protein	-
QMG94_RS07625 (1499554)	1499554..1500009	-	456	WP_000273724.1	hypothetical protein	-
QMG94_RS07630 (1500088)	1500088..1501179	+	1092	WP_001205823.1	hypothetical protein	-
QMG94_RS07635 (1501186)	1501186..1501932	+	747	WP_000788750.1	ATP-binding protein	-
QMG94_RS07640 (1501954)	1501954..1502724	+	771	WP_000451007.1	DUF1627 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1474318..1538369	64051

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10978.84 Da
• Isoelectric Point: 10.1360

>T43091 WP_001303876.1 NZ_AP027159:c1497938-1497651 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Nucleotide

• Length: 288 bp

>T43091 NZ_AP027159:c1497938-1497651 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7025.80 Da
• Isoelectric Point: 4.0270

>AT43091 WP_000536233.1 NZ_AP027159:c1498129-1497938 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Nucleotide

• Length: 192 bp

>AT43091 NZ_AP027159:c1498129-1497938 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA