Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1385362..1386206 Replicon chromosome
Accession NZ_AP027159
Organism Escherichia coli strain 2313

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag QMG94_RS06930 Protein ID WP_000854686.1
Coordinates 1385823..1386206 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag QMG94_RS06925 Protein ID WP_001285602.1
Coordinates 1385362..1385742 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG94_RS06890 (1381610) 1381610..1382065 + 456 WP_000581506.1 IrmA family protein -
QMG94_RS06895 (1382166) 1382166..1382374 + 209 Protein_1350 DUF905 family protein -
QMG94_RS06900 (1382475) 1382475..1383296 + 822 WP_001761104.1 DUF932 domain-containing protein -
QMG94_RS06905 (1383388) 1383388..1383873 + 486 WP_000214307.1 antirestriction protein -
QMG94_RS06910 (1383889) 1383889..1384365 + 477 WP_001186726.1 RadC family protein -
QMG94_RS06915 (1384428) 1384428..1384649 + 222 WP_000692298.1 DUF987 domain-containing protein -
QMG94_RS06920 (1384668) 1384668..1385351 + 684 WP_000086768.1 hypothetical protein -
QMG94_RS06925 (1385362) 1385362..1385742 + 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QMG94_RS06930 (1385823) 1385823..1386206 + 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
QMG94_RS06935 (1386203) 1386203..1386691 + 489 WP_001054233.1 DUF5983 family protein -
QMG94_RS06940 (1386708) 1386708..1386905 + 198 WP_000839253.1 DUF957 domain-containing protein -
QMG94_RS06945 (1386990) 1386990..1387832 + 843 WP_001431817.1 DUF4942 domain-containing protein -
QMG94_RS06955 (1388303) 1388303..1389241 + 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
QMG94_RS06960 (1389296) 1389296..1390033 + 738 WP_000283664.1 zinc-binding phosphatase -
QMG94_RS06965 (1390057) 1390057..1390611 + 555 WP_001001902.1 molecular chaperone YcdY -
QMG94_RS06970 (1390713) 1390713..1391204 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T43090 WP_000854686.1 NZ_AP027159:1385823-1386206 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T43090 NZ_AP027159:1385823-1386206 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT43090 WP_001285602.1 NZ_AP027159:1385362-1385742 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT43090 NZ_AP027159:1385362-1385742 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References