Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
| Location | 19790..20451 | Replicon | plasmid pDSM21852-1 |
| Accession | NZ_AP027150 | ||
| Organism | Methylocystis bryophila strain DSM 21852 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | QMG80_RS21040 | Protein ID | WP_281926536.1 |
| Coordinates | 20023..20451 (+) | Length | 143 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | QMG80_RS21035 | Protein ID | WP_085773936.1 |
| Coordinates | 19790..20026 (+) | Length | 79 a.a. |
Genomic Context
Location: 15786..17009 (1224 bp)
Type: Others
Protein ID: WP_085773938.1
Type: Others
Protein ID: WP_085773938.1
Location: 17006..17965 (960 bp)
Type: Others
Protein ID: WP_085774007.1
Type: Others
Protein ID: WP_085774007.1
Location: 18184..19518 (1335 bp)
Type: Others
Protein ID: WP_085773937.1
Type: Others
Protein ID: WP_085773937.1
Location: 19790..20026 (237 bp)
Type: Antitoxin
Protein ID: WP_085773936.1
Type: Antitoxin
Protein ID: WP_085773936.1
Location: 20023..20451 (429 bp)
Type: Toxin
Protein ID: WP_281926536.1
Type: Toxin
Protein ID: WP_281926536.1
Location: 21858..22808 (951 bp)
Type: Others
Protein ID: WP_158658929.1
Type: Others
Protein ID: WP_158658929.1
Location: 22815..23519 (705 bp)
Type: Others
Protein ID: WP_085773932.1
Type: Others
Protein ID: WP_085773932.1
Location: 23812..24117 (306 bp)
Type: Others
Protein ID: WP_085773931.1
Type: Others
Protein ID: WP_085773931.1
Location: 24120..24539 (420 bp)
Type: Others
Protein ID: WP_085773930.1
Type: Others
Protein ID: WP_085773930.1
Location: 24659..24997 (339 bp)
Type: Others
Protein ID: WP_210190845.1
Type: Others
Protein ID: WP_210190845.1
Location: 20490..21623 (1134 bp)
Type: Others
Protein ID: WP_085773934.1
Type: Others
Protein ID: WP_085773934.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMG80_RS21020 (DSM21852_42200) | 15786..17009 | + | 1224 | WP_085773938.1 | plasmid partitioning protein RepA | - |
| QMG80_RS21025 (DSM21852_42210) | 17006..17965 | + | 960 | WP_085774007.1 | plasmid partitioning protein RepB | - |
| QMG80_RS21030 (DSM21852_42220) | 18184..19518 | + | 1335 | WP_085773937.1 | plasmid replication protein RepC | - |
| QMG80_RS21035 (DSM21852_42230) | 19790..20026 | + | 237 | WP_085773936.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| QMG80_RS21040 (DSM21852_42240) | 20023..20451 | + | 429 | WP_281926536.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| QMG80_RS21045 (DSM21852_42250) | 20490..21623 | - | 1134 | WP_085773934.1 | tyrosine-type recombinase/integrase | - |
| QMG80_RS21050 (DSM21852_42260) | 21858..22808 | + | 951 | WP_158658929.1 | DUF1403 family protein | - |
| QMG80_RS21055 (DSM21852_42270) | 22815..23519 | + | 705 | WP_085773932.1 | SMC-Scp complex subunit ScpB | - |
| QMG80_RS21060 (DSM21852_42280) | 23812..24117 | + | 306 | WP_085773931.1 | type II toxin-antitoxin system MqsR family toxin | - |
| QMG80_RS21065 (DSM21852_42290) | 24120..24539 | + | 420 | WP_085773930.1 | type II toxin-antitoxin system MqsA family antitoxin | - |
| QMG80_RS21070 (DSM21852_42300) | 24659..24997 | + | 339 | WP_210190845.1 | hypothetical protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..174578 | 174578 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 143 a.a. Molecular weight: 15390.49 Da Isoelectric Point: 4.5070
>T43044 WP_281926536.1 NZ_AP027150:20023-20451 [Methylocystis bryophila]
MMFVDTSAIVAILCGEDDAAELAGRLASAERRFTSPVVRLEACMVLALKLDITPAQANALFEDFLDEAHVSITPINDKIG
VLAVACFESYGKGRHPARLNLGDCLSYACAKAYRSALLFKEDDFSQTDVETTSARARNDPQS
MMFVDTSAIVAILCGEDDAAELAGRLASAERRFTSPVVRLEACMVLALKLDITPAQANALFEDFLDEAHVSITPINDKIG
VLAVACFESYGKGRHPARLNLGDCLSYACAKAYRSALLFKEDDFSQTDVETTSARARNDPQS
Download Length: 429 bp
>T43044 NZ_AP027150:20023-20451 [Methylocystis bryophila]
ATGATGTTCGTGGACACCTCCGCGATCGTAGCGATCCTCTGCGGCGAGGATGACGCTGCCGAGCTTGCGGGACGCCTCGC
GTCGGCGGAGCGGCGTTTTACGTCGCCGGTCGTCCGGCTGGAGGCGTGCATGGTGCTGGCGTTAAAGCTCGACATCACGC
CGGCGCAGGCAAACGCTCTGTTCGAGGATTTTCTCGACGAGGCGCATGTCTCGATCACGCCGATCAATGACAAGATTGGC
GTTCTCGCCGTCGCCTGCTTCGAGAGCTACGGCAAGGGACGGCATCCGGCGCGATTGAATCTCGGCGACTGCCTCTCCTA
TGCGTGCGCCAAGGCCTACCGCTCGGCGCTACTGTTCAAGGAAGACGATTTTTCGCAAACAGACGTCGAAACGACGAGCG
CGCGGGCGCGAAACGACCCGCAAAGCTAG
ATGATGTTCGTGGACACCTCCGCGATCGTAGCGATCCTCTGCGGCGAGGATGACGCTGCCGAGCTTGCGGGACGCCTCGC
GTCGGCGGAGCGGCGTTTTACGTCGCCGGTCGTCCGGCTGGAGGCGTGCATGGTGCTGGCGTTAAAGCTCGACATCACGC
CGGCGCAGGCAAACGCTCTGTTCGAGGATTTTCTCGACGAGGCGCATGTCTCGATCACGCCGATCAATGACAAGATTGGC
GTTCTCGCCGTCGCCTGCTTCGAGAGCTACGGCAAGGGACGGCATCCGGCGCGATTGAATCTCGGCGACTGCCTCTCCTA
TGCGTGCGCCAAGGCCTACCGCTCGGCGCTACTGTTCAAGGAAGACGATTTTTCGCAAACAGACGTCGAAACGACGAGCG
CGCGGGCGCGAAACGACCCGCAAAGCTAG
Antitoxin
Download Length: 79 a.a. Molecular weight: 8917.49 Da Isoelectric Point: 10.8628
>AT43044 WP_085773936.1 NZ_AP027150:19790-20026 [Methylocystis bryophila]
MLSIRDPRAAELAKLLAARRKTTMTEAIIVALENELKRERERVPLPERLARLAVKARKLAGPKGRDVPKEELDEFWGQ
MLSIRDPRAAELAKLLAARRKTTMTEAIIVALENELKRERERVPLPERLARLAVKARKLAGPKGRDVPKEELDEFWGQ
Download Length: 237 bp
>AT43044 NZ_AP027150:19790-20026 [Methylocystis bryophila]
ATGCTCAGCATACGGGACCCGCGAGCGGCAGAGCTCGCAAAGCTGCTCGCCGCTCGGCGCAAAACCACGATGACCGAAGC
CATTATCGTGGCGTTGGAGAATGAGTTGAAACGGGAGCGCGAGCGGGTTCCGCTGCCCGAGCGACTTGCGCGCTTGGCCG
TAAAAGCTCGGAAGCTCGCCGGGCCAAAGGGCCGTGACGTCCCCAAGGAAGAACTCGACGAATTCTGGGGCCAATGA
ATGCTCAGCATACGGGACCCGCGAGCGGCAGAGCTCGCAAAGCTGCTCGCCGCTCGGCGCAAAACCACGATGACCGAAGC
CATTATCGTGGCGTTGGAGAATGAGTTGAAACGGGAGCGCGAGCGGGTTCCGCTGCCCGAGCGACTTGCGCGCTTGGCCG
TAAAAGCTCGGAAGCTCGCCGGGCCAAAGGGCCGTGACGTCCCCAAGGAAGAACTCGACGAATTCTGGGGCCAATGA