Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4023294..4023997 Replicon chromosome
Accession NZ_AP027149
Organism Methylocystis bryophila strain DSM 21852

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QMG80_RS18555 Protein ID WP_085770515.1
Coordinates 4023590..4023997 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QMG80_RS18550 Protein ID WP_085770514.1
Coordinates 4023294..4023581 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG80_RS18520 (DSM21852_37150) 4018610..4018798 + 189 Protein_3651 LLM class flavin-dependent oxidoreductase -
QMG80_RS18525 (DSM21852_37160) 4018887..4020128 + 1242 WP_085770510.1 SfnB family sulfur acquisition oxidoreductase -
QMG80_RS18530 4020132..4020254 + 123 WP_280950007.1 hypothetical protein -
QMG80_RS18535 4020296..4020943 + 648 Protein_3654 LysR substrate-binding domain-containing protein -
QMG80_RS18540 (DSM21852_37190) 4021237..4022166 + 930 WP_085770511.1 MBL fold metallo-hydrolase -
QMG80_RS18545 (DSM21852_37200) 4022661..4023014 - 354 WP_085770513.1 DsrE family protein -
QMG80_RS18550 (DSM21852_37210) 4023294..4023581 + 288 WP_085770514.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QMG80_RS18555 (DSM21852_37220) 4023590..4023997 + 408 WP_085770515.1 PIN domain-containing protein Toxin
QMG80_RS18560 (DSM21852_37230) 4024107..4025714 - 1608 WP_085770516.1 efflux transporter outer membrane subunit -
QMG80_RS18565 (DSM21852_37240) 4025711..4026910 - 1200 WP_085770517.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-126)

Antitoxin

SpoVT-AbrB domain

(18-54)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14918.15 Da        Isoelectric Point: 6.3580

>T43042 WP_085770515.1 NZ_AP027149:4023590-4023997 [Methylocystis bryophila]
MFCLDTNIVIFALNKRRPWIATRLDNELRAGTALIVPAIVLFELNYGIAKSDRADQARALLDGFLSAGIGQPAFDAEDAR
EAADIRAFLERQGTPIGPFDYLVAAQARRRGAALVTLNRREFERVPGLMVTDWAA

Download         Length: 408 bp

>T43042 NZ_AP027149:4023590-4023997 [Methylocystis bryophila]
ATGTTTTGTCTCGACACGAACATCGTCATCTTCGCCTTGAACAAGCGGAGGCCCTGGATCGCCACGAGGCTCGATAATGA
GCTGAGGGCGGGAACGGCGCTCATCGTCCCCGCGATCGTGCTGTTCGAGCTCAACTACGGAATCGCCAAGAGCGACCGAG
CCGATCAAGCGCGCGCCCTGCTCGATGGCTTCTTGTCCGCCGGGATAGGCCAGCCGGCCTTCGACGCGGAGGATGCGCGC
GAGGCCGCGGACATAAGGGCGTTCCTCGAACGGCAAGGGACGCCGATCGGCCCCTTCGACTATCTCGTCGCGGCGCAGGC
GCGGCGGCGCGGCGCGGCGCTGGTGACGCTCAACCGCCGCGAGTTCGAGCGCGTGCCCGGCCTGATGGTGACGGATTGGG
CGGCATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10494.93 Da        Isoelectric Point: 4.9057

>AT43042 WP_085770514.1 NZ_AP027149:4023294-4023581 [Methylocystis bryophila]
MTASAGKPAQEKATAKLFMHGRSQAVRLPKEFRFEGKEVRVSKVGDKVILEPLKKEPFDVEAWRGSLDALGARDFLPDGL
PDDPPLEPDDSISFD

Download         Length: 288 bp

>AT43042 NZ_AP027149:4023294-4023581 [Methylocystis bryophila]
ATGACCGCCAGCGCCGGCAAGCCCGCCCAAGAGAAAGCGACCGCCAAGCTGTTCATGCACGGCCGCAGCCAGGCTGTGCG
CCTGCCGAAGGAGTTCCGCTTCGAGGGGAAAGAGGTGCGCGTCAGCAAGGTAGGCGACAAGGTGATCTTGGAGCCTTTGA
AAAAGGAGCCGTTCGACGTGGAAGCCTGGCGCGGGAGTCTCGACGCCTTGGGCGCGCGGGATTTCTTGCCCGACGGTCTG
CCCGATGATCCGCCCCTCGAGCCCGACGATTCGATATCATTCGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References