Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicB(antitoxin) |
| Location | 3785904..3786513 | Replicon | chromosome |
| Accession | NZ_AP027149 | ||
| Organism | Methylocystis bryophila strain DSM 21852 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | QMG80_RS17485 | Protein ID | WP_085770347.1 |
| Coordinates | 3786328..3786513 (-) | Length | 62 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | QMG80_RS17480 | Protein ID | WP_085770346.1 |
| Coordinates | 3785904..3786323 (-) | Length | 140 a.a. |
Genomic Context
Location: 3782331..3783041 (711 bp)
Type: Others
Protein ID: WP_245300039.1
Type: Others
Protein ID: WP_245300039.1
Location: 3783093..3784148 (1056 bp)
Type: Others
Protein ID: WP_085770344.1
Type: Others
Protein ID: WP_085770344.1
Location: 3789188..3789610 (423 bp)
Type: Others
Protein ID: WP_085770352.1
Type: Others
Protein ID: WP_085770352.1
Location: 3781627..3781752 (126 bp)
Type: Others
Protein ID: WP_280950004.1
Type: Others
Protein ID: WP_280950004.1
Location: 3784260..3785864 (1605 bp)
Type: Others
Protein ID: WP_085770345.1
Type: Others
Protein ID: WP_085770345.1
Location: 3785904..3786323 (420 bp)
Type: Antitoxin
Protein ID: WP_085770346.1
Type: Antitoxin
Protein ID: WP_085770346.1
Location: 3786328..3786513 (186 bp)
Type: Toxin
Protein ID: WP_085770347.1
Type: Toxin
Protein ID: WP_085770347.1
Location: 3786581..3787189 (609 bp)
Type: Others
Protein ID: WP_085770348.1
Type: Others
Protein ID: WP_085770348.1
Location: 3787186..3787647 (462 bp)
Type: Others
Protein ID: WP_085770349.1
Type: Others
Protein ID: WP_085770349.1
Location: 3787705..3788796 (1092 bp)
Type: Others
Protein ID: WP_245300040.1
Type: Others
Protein ID: WP_245300040.1
Location: 3789762..3791402 (1641 bp)
Type: Others
Protein ID: WP_085770353.1
Type: Others
Protein ID: WP_085770353.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMG80_RS17460 (DSM21852_35030) | 3781627..3781752 | - | 126 | WP_280950004.1 | hypothetical protein | - |
| QMG80_RS17465 (DSM21852_35040) | 3782331..3783041 | + | 711 | WP_245300039.1 | M15 family metallopeptidase | - |
| QMG80_RS17470 (DSM21852_35050) | 3783093..3784148 | + | 1056 | WP_085770344.1 | NAD(P)-dependent alcohol dehydrogenase | - |
| QMG80_RS17475 (DSM21852_35060) | 3784260..3785864 | - | 1605 | WP_085770345.1 | peptide chain release factor 3 | - |
| QMG80_RS17480 (DSM21852_35070) | 3785904..3786323 | - | 420 | WP_085770346.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| QMG80_RS17485 (DSM21852_35080) | 3786328..3786513 | - | 186 | WP_085770347.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| QMG80_RS17490 (DSM21852_35090) | 3786581..3787189 | - | 609 | WP_085770348.1 | cob(I)yrinic acid a,c-diamide adenosyltransferase | - |
| QMG80_RS17495 (DSM21852_35100) | 3787186..3787647 | - | 462 | WP_085770349.1 | preQ(1) synthase | - |
| QMG80_RS17500 (DSM21852_35110) | 3787705..3788796 | - | 1092 | WP_245300040.1 | DUF2778 domain-containing protein | - |
| QMG80_RS17505 (DSM21852_35120) | 3789188..3789610 | + | 423 | WP_085770352.1 | hypothetical protein | - |
| QMG80_RS17510 (DSM21852_35130) | 3789762..3791402 | - | 1641 | WP_085770353.1 | 2-isopropylmalate synthase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 62 a.a. Molecular weight: 6485.69 Da Isoelectric Point: 11.1039
>T43041 WP_085770347.1 NZ_AP027149:c3786513-3786328 [Methylocystis bryophila]
MNSAQAKRYLAKKGATFAPGKGGPLIVTLNGKRSVLPQHGGSKEIGKGLWLAILKQLDIKE
MNSAQAKRYLAKKGATFAPGKGGPLIVTLNGKRSVLPQHGGSKEIGKGLWLAILKQLDIKE
Download Length: 186 bp
>T43041 NZ_AP027149:c3786513-3786328 [Methylocystis bryophila]
ATGAACAGCGCTCAGGCCAAGCGCTATCTGGCCAAGAAGGGCGCAACCTTCGCGCCTGGCAAAGGCGGCCCTCTGATCGT
GACGCTGAATGGCAAGCGCTCGGTGCTCCCGCAGCACGGCGGGTCGAAGGAGATCGGCAAGGGCCTGTGGCTGGCAATCT
TGAAGCAACTCGACATCAAGGAGTGA
ATGAACAGCGCTCAGGCCAAGCGCTATCTGGCCAAGAAGGGCGCAACCTTCGCGCCTGGCAAAGGCGGCCCTCTGATCGT
GACGCTGAATGGCAAGCGCTCGGTGCTCCCGCAGCACGGCGGGTCGAAGGAGATCGGCAAGGGCCTGTGGCTGGCAATCT
TGAAGCAACTCGACATCAAGGAGTGA
Antitoxin
Download Length: 140 a.a. Molecular weight: 14863.17 Da Isoelectric Point: 5.2520
>AT43041 WP_085770346.1 NZ_AP027149:c3786323-3785904 [Methylocystis bryophila]
MRYAVTLVPDDNGTLLVTAPDIPEAVTFGEDREDALARAADAIETAIMGFMSAREDIPSPKAKGQDYVSLAALSVAKIEL
YRAMRADGVGKAALAKRLGVALPQIDRLLDLRHASRLDAIERAFAALGRTMEVVIRAAA
MRYAVTLVPDDNGTLLVTAPDIPEAVTFGEDREDALARAADAIETAIMGFMSAREDIPSPKAKGQDYVSLAALSVAKIEL
YRAMRADGVGKAALAKRLGVALPQIDRLLDLRHASRLDAIERAFAALGRTMEVVIRAAA
Download Length: 420 bp
>AT43041 NZ_AP027149:c3786323-3785904 [Methylocystis bryophila]
ATGCGCTACGCCGTGACTCTCGTTCCCGACGACAATGGTACGCTTCTCGTCACCGCGCCTGATATTCCCGAGGCCGTCAC
CTTTGGCGAGGACCGGGAAGACGCGCTGGCGCGCGCCGCCGACGCCATCGAAACCGCGATCATGGGCTTCATGTCGGCGC
GCGAGGACATCCCGTCCCCCAAGGCGAAAGGGCAGGACTACGTCTCCTTGGCCGCGCTCTCCGTCGCCAAGATCGAGCTT
TACCGCGCCATGCGGGCGGATGGAGTCGGCAAGGCGGCGCTCGCCAAGCGCCTCGGCGTCGCTTTGCCGCAGATTGACCG
GCTGCTCGACCTTCGCCACGCTTCCCGCCTCGATGCGATCGAGCGGGCCTTTGCCGCGCTGGGGCGAACCATGGAGGTTG
TCATCAGAGCCGCGGCGTGA
ATGCGCTACGCCGTGACTCTCGTTCCCGACGACAATGGTACGCTTCTCGTCACCGCGCCTGATATTCCCGAGGCCGTCAC
CTTTGGCGAGGACCGGGAAGACGCGCTGGCGCGCGCCGCCGACGCCATCGAAACCGCGATCATGGGCTTCATGTCGGCGC
GCGAGGACATCCCGTCCCCCAAGGCGAAAGGGCAGGACTACGTCTCCTTGGCCGCGCTCTCCGTCGCCAAGATCGAGCTT
TACCGCGCCATGCGGGCGGATGGAGTCGGCAAGGCGGCGCTCGCCAAGCGCCTCGGCGTCGCTTTGCCGCAGATTGACCG
GCTGCTCGACCTTCGCCACGCTTCCCGCCTCGATGCGATCGAGCGGGCCTTTGCCGCGCTGGGGCGAACCATGGAGGTTG
TCATCAGAGCCGCGGCGTGA