Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 3785904..3786513 Replicon chromosome
Accession NZ_AP027149
Organism Methylocystis bryophila strain DSM 21852

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QMG80_RS17485 Protein ID WP_085770347.1
Coordinates 3786328..3786513 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QMG80_RS17480 Protein ID WP_085770346.1
Coordinates 3785904..3786323 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG80_RS17460 (DSM21852_35030) 3781627..3781752 - 126 WP_280950004.1 hypothetical protein -
QMG80_RS17465 (DSM21852_35040) 3782331..3783041 + 711 WP_245300039.1 M15 family metallopeptidase -
QMG80_RS17470 (DSM21852_35050) 3783093..3784148 + 1056 WP_085770344.1 NAD(P)-dependent alcohol dehydrogenase -
QMG80_RS17475 (DSM21852_35060) 3784260..3785864 - 1605 WP_085770345.1 peptide chain release factor 3 -
QMG80_RS17480 (DSM21852_35070) 3785904..3786323 - 420 WP_085770346.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QMG80_RS17485 (DSM21852_35080) 3786328..3786513 - 186 WP_085770347.1 type II toxin-antitoxin system HicA family toxin Toxin
QMG80_RS17490 (DSM21852_35090) 3786581..3787189 - 609 WP_085770348.1 cob(I)yrinic acid a,c-diamide adenosyltransferase -
QMG80_RS17495 (DSM21852_35100) 3787186..3787647 - 462 WP_085770349.1 preQ(1) synthase -
QMG80_RS17500 (DSM21852_35110) 3787705..3788796 - 1092 WP_245300040.1 DUF2778 domain-containing protein -
QMG80_RS17505 (DSM21852_35120) 3789188..3789610 + 423 WP_085770352.1 hypothetical protein -
QMG80_RS17510 (DSM21852_35130) 3789762..3791402 - 1641 WP_085770353.1 2-isopropylmalate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-62)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6485.69 Da        Isoelectric Point: 11.1039

>T43041 WP_085770347.1 NZ_AP027149:c3786513-3786328 [Methylocystis bryophila]
MNSAQAKRYLAKKGATFAPGKGGPLIVTLNGKRSVLPQHGGSKEIGKGLWLAILKQLDIKE

Download         Length: 186 bp

>T43041 NZ_AP027149:c3786513-3786328 [Methylocystis bryophila]
ATGAACAGCGCTCAGGCCAAGCGCTATCTGGCCAAGAAGGGCGCAACCTTCGCGCCTGGCAAAGGCGGCCCTCTGATCGT
GACGCTGAATGGCAAGCGCTCGGTGCTCCCGCAGCACGGCGGGTCGAAGGAGATCGGCAAGGGCCTGTGGCTGGCAATCT
TGAAGCAACTCGACATCAAGGAGTGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 14863.17 Da        Isoelectric Point: 5.2520

>AT43041 WP_085770346.1 NZ_AP027149:c3786323-3785904 [Methylocystis bryophila]
MRYAVTLVPDDNGTLLVTAPDIPEAVTFGEDREDALARAADAIETAIMGFMSAREDIPSPKAKGQDYVSLAALSVAKIEL
YRAMRADGVGKAALAKRLGVALPQIDRLLDLRHASRLDAIERAFAALGRTMEVVIRAAA

Download         Length: 420 bp

>AT43041 NZ_AP027149:c3786323-3785904 [Methylocystis bryophila]
ATGCGCTACGCCGTGACTCTCGTTCCCGACGACAATGGTACGCTTCTCGTCACCGCGCCTGATATTCCCGAGGCCGTCAC
CTTTGGCGAGGACCGGGAAGACGCGCTGGCGCGCGCCGCCGACGCCATCGAAACCGCGATCATGGGCTTCATGTCGGCGC
GCGAGGACATCCCGTCCCCCAAGGCGAAAGGGCAGGACTACGTCTCCTTGGCCGCGCTCTCCGTCGCCAAGATCGAGCTT
TACCGCGCCATGCGGGCGGATGGAGTCGGCAAGGCGGCGCTCGCCAAGCGCCTCGGCGTCGCTTTGCCGCAGATTGACCG
GCTGCTCGACCTTCGCCACGCTTCCCGCCTCGATGCGATCGAGCGGGCCTTTGCCGCGCTGGGGCGAACCATGGAGGTTG
TCATCAGAGCCGCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References