Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2289547..2290178 Replicon chromosome
Accession NZ_AP027149
Organism Methylocystis bryophila strain DSM 21852

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QMG80_RS10715 Protein ID WP_085772819.1
Coordinates 2289547..2289945 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QMG80_RS10720 Protein ID WP_085773816.1
Coordinates 2289945..2290178 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG80_RS10700 (DSM21852_21570) 2284839..2285840 + 1002 WP_085772816.1 MoxR family ATPase -
QMG80_RS10705 (DSM21852_21580) 2285843..2286778 + 936 WP_085772817.1 DUF58 domain-containing protein -
QMG80_RS10710 (DSM21852_21590) 2286769..2289531 + 2763 WP_085772818.1 DUF4159 domain-containing protein -
QMG80_RS10715 (DSM21852_21600) 2289547..2289945 - 399 WP_085772819.1 type II toxin-antitoxin system VapC family toxin Toxin
QMG80_RS10720 (DSM21852_21610) 2289945..2290178 - 234 WP_085773816.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QMG80_RS10725 (DSM21852_21620) 2290314..2292767 + 2454 WP_281926443.1 phosphoketolase family protein -
QMG80_RS10730 (DSM21852_21630) 2292912..2293502 + 591 WP_085772821.1 histidine phosphatase family protein -
QMG80_RS10735 (DSM21852_21640) 2293640..2294227 - 588 WP_085772822.1 hypothetical protein -
QMG80_RS10740 (DSM21852_21650) 2294284..2295006 - 723 WP_245299970.1 DUF3142 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14824.07 Da        Isoelectric Point: 7.2911

>T43040 WP_085772819.1 NZ_AP027149:c2289945-2289547 [Methylocystis bryophila]
MLNYMLDTNICIYVMKTYPPALRDKFNGLAEQLCISSITLGELHYGAEKSARRTENLKAIEQFVARLEVLPFAEKAAAHY
GQVRAELERAGTPCGPHDMQIGGHARSEGLIVVTNNFREFARMPGVRVENWV

Download         Length: 399 bp

>T43040 NZ_AP027149:c2289945-2289547 [Methylocystis bryophila]
ATGCTCAACTATATGCTGGACACAAACATCTGCATTTACGTGATGAAGACTTATCCACCCGCCCTCCGCGACAAATTCAA
TGGGTTGGCGGAGCAGCTTTGCATATCGAGCATCACGCTGGGCGAACTGCATTATGGCGCGGAGAAGTCGGCGCGACGAA
CCGAGAACTTAAAGGCAATCGAGCAATTCGTGGCGCGGCTGGAAGTGCTTCCGTTCGCGGAGAAGGCTGCCGCGCATTAC
GGGCAAGTCCGAGCCGAACTGGAGCGGGCCGGAACGCCTTGTGGTCCGCATGACATGCAGATCGGCGGTCATGCCCGCAG
CGAGGGGCTCATCGTCGTCACCAACAATTTTCGAGAATTCGCAAGAATGCCGGGCGTGAGAGTGGAGAATTGGGTGTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8912.17 Da        Isoelectric Point: 8.9533

>AT43040 WP_085773816.1 NZ_AP027149:c2290178-2289945 [Methylocystis bryophila]
MTRSTVFTSNRSQAVRLPKAVAFPEEVHHVDILKIGRTRVIAPQGKRWDDLFLHGPRVTDDFMVEREQPPAETREPF

Download         Length: 234 bp

>AT43040 NZ_AP027149:c2290178-2289945 [Methylocystis bryophila]
ATGACCCGTTCGACCGTCTTCACCAGCAATCGCAGCCAGGCCGTTCGCCTTCCAAAGGCCGTCGCCTTCCCGGAGGAGGT
CCATCACGTCGATATCCTCAAGATCGGCCGCACTCGCGTGATCGCGCCTCAGGGCAAAAGGTGGGACGACCTTTTCTTGC
ACGGGCCGCGCGTCACTGACGATTTCATGGTCGAGCGAGAGCAACCGCCCGCAGAGACTCGCGAGCCTTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References