Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2110628..2111256 Replicon chromosome
Accession NZ_AP027149
Organism Methylocystis bryophila strain DSM 21852

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QMG80_RS09985 Protein ID WP_085772676.1
Coordinates 2110858..2111256 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QMG80_RS09980 Protein ID WP_085772675.1
Coordinates 2110628..2110861 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG80_RS09965 (DSM21852_20030) 2106444..2108705 - 2262 WP_085772673.1 TonB-dependent receptor -
QMG80_RS09970 (DSM21852_20040) 2108940..2110013 + 1074 WP_245299967.1 recombinase RecA -
QMG80_RS09975 (DSM21852_20050) 2110260..2110505 + 246 WP_085772674.1 exodeoxyribonuclease VII small subunit -
QMG80_RS09980 (DSM21852_20060) 2110628..2110861 + 234 WP_085772675.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QMG80_RS09985 (DSM21852_20070) 2110858..2111256 + 399 WP_085772676.1 type II toxin-antitoxin system VapC family toxin Toxin
QMG80_RS09990 (DSM21852_20090) 2111784..2113754 - 1971 WP_085772677.1 protein meaA -
QMG80_RS09995 (DSM21852_20100) 2114205..2114951 - 747 WP_085772678.1 YebC/PmpR family DNA-binding transcriptional regulator -
QMG80_RS10000 (DSM21852_20110) 2115183..2116148 + 966 WP_085772679.1 TIGR00730 family Rossman fold protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

SpoVT-AbrB domain

(9-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14378.57 Da        Isoelectric Point: 5.2338

>T43039 WP_085772676.1 NZ_AP027149:2110858-2111256 [Methylocystis bryophila]
MKYLLDTNIISDLIKNPRGRAAEHIGRVGEVNVCTSMVVAAELRYGCVKAGSTRLAEAVEKLLAEIDLLPFEVPADAEYG
RLRARLEQQGKTIGSNDLLIAAHALAIDATIVTANVSEFSRVEGLRVENWLC

Download         Length: 399 bp

>T43039 NZ_AP027149:2110858-2111256 [Methylocystis bryophila]
CTGAAATATCTCTTAGACACCAACATCATCTCCGACCTGATAAAAAATCCTCGGGGCCGTGCCGCGGAGCACATCGGGCG
CGTCGGCGAGGTCAACGTCTGCACGAGCATGGTCGTGGCCGCCGAGCTTCGCTACGGATGCGTGAAAGCGGGCTCGACGC
GTCTTGCGGAAGCCGTCGAAAAGCTTCTAGCCGAGATTGACCTTCTTCCATTTGAAGTCCCGGCCGACGCGGAATATGGG
CGTCTTCGCGCGCGCCTTGAGCAGCAAGGGAAGACGATCGGCTCGAACGATCTCTTGATTGCCGCGCACGCTCTGGCCAT
AGACGCCACGATCGTCACGGCCAATGTCAGCGAGTTCTCGCGGGTGGAAGGATTGAGGGTCGAAAACTGGCTCTGTTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8939.38 Da        Isoelectric Point: 4.8660

>AT43039 WP_085772675.1 NZ_AP027149:2110628-2110861 [Methylocystis bryophila]
MEARRVRLFRNGRNQAVRIPVEFELPGDEALLLREGDRLVLLPTRKRGLLGLLATMEPLDEDFPEIEDRPPAPERMF

Download         Length: 234 bp

>AT43039 NZ_AP027149:2110628-2110861 [Methylocystis bryophila]
ATGGAAGCGAGGCGCGTGAGGCTGTTCAGAAACGGACGCAATCAAGCCGTGCGGATTCCTGTCGAATTCGAGTTGCCCGG
CGATGAGGCGCTCTTGCTGCGCGAAGGCGATCGTCTCGTGCTTTTGCCGACGCGTAAGCGCGGTCTCTTGGGCCTGCTCG
CGACGATGGAGCCTCTCGACGAGGACTTTCCCGAGATTGAGGATCGACCGCCAGCGCCGGAGCGAATGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References