Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1446343..1446971 Replicon chromosome
Accession NZ_AP027149
Organism Methylocystis bryophila strain DSM 21852

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QMG80_RS06810 Protein ID WP_085772130.1
Coordinates 1446343..1446738 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QMG80_RS06815 Protein ID WP_085772131.1
Coordinates 1446738..1446971 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG80_RS06780 (DSM21852_13650) 1441775..1442542 - 768 WP_245299923.1 DedA family protein -
QMG80_RS06785 (DSM21852_13660) 1442658..1443848 + 1191 WP_085772126.1 elongation factor Tu -
QMG80_RS06790 1444085..1444972 + 888 WP_158658770.1 hypothetical protein -
QMG80_RS06795 (DSM21852_13670) 1445134..1445361 - 228 WP_085772127.1 hypothetical protein -
QMG80_RS06800 (DSM21852_13680) 1445458..1445967 - 510 WP_085772128.1 GNAT family N-acetyltransferase -
QMG80_RS06805 (DSM21852_13690) 1445971..1446273 - 303 WP_085772129.1 DUF1778 domain-containing protein -
QMG80_RS06810 (DSM21852_13700) 1446343..1446738 - 396 WP_085772130.1 PIN domain-containing protein Toxin
QMG80_RS06815 (DSM21852_13710) 1446738..1446971 - 234 WP_085772131.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QMG80_RS06820 (DSM21852_13720) 1447133..1447357 - 225 WP_085772132.1 hypothetical protein -
QMG80_RS06825 (DSM21852_13730) 1447556..1448413 + 858 WP_085772133.1 DUF1499 domain-containing protein -
QMG80_RS06830 (DSM21852_13740) 1448379..1450187 - 1809 WP_085772134.1 M3 family oligoendopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

SpoVT-AbrB domain

(10-43)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14263.47 Da        Isoelectric Point: 6.4608

>T43038 WP_085772130.1 NZ_AP027149:c1446738-1446343 [Methylocystis bryophila]
MRYMLDTNICAAVIKRREKRVLGRFDAEAGRMCVSTITLSEILFGAEKKASPALDAAVRDLAACIGVVAYDEAAASHYGQ
LRAELERLGATLGANDLFIAAHARSLGLILVTDDAAFERVPGLRVENWLRE

Download         Length: 396 bp

>T43038 NZ_AP027149:c1446738-1446343 [Methylocystis bryophila]
ATGCGCTATATGCTCGACACGAATATTTGCGCCGCCGTCATCAAGCGGCGTGAAAAGAGGGTGTTAGGCAGGTTCGACGC
CGAGGCGGGACGCATGTGCGTCTCGACGATCACTTTGAGCGAAATATTGTTCGGCGCAGAAAAGAAAGCGAGCCCCGCCC
TCGACGCGGCGGTGCGCGACCTTGCCGCCTGCATCGGCGTGGTCGCTTACGACGAAGCCGCGGCCTCGCATTATGGGCAA
TTGCGCGCCGAGCTCGAACGACTGGGCGCGACGCTCGGCGCGAATGATCTCTTCATCGCCGCCCACGCCCGCTCATTGGG
GCTTATCCTCGTGACCGACGACGCGGCTTTTGAGCGCGTCCCGGGATTGCGGGTCGAGAATTGGCTGCGCGAGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8564.85 Da        Isoelectric Point: 7.0118

>AT43038 WP_085772131.1 NZ_AP027149:c1446971-1446738 [Methylocystis bryophila]
MTTAATTLFLSNKTQALRLPKAVAFPEGVKEVDIVVVGESRIVSPAGKRFTEWAKRHPPFPDFERPTQPPLDDEAIF

Download         Length: 234 bp

>AT43038 NZ_AP027149:c1446971-1446738 [Methylocystis bryophila]
ATGACCACCGCCGCCACCACCCTCTTTCTCAGCAATAAGACACAGGCCCTGCGCCTGCCGAAGGCCGTCGCTTTCCCTGA
GGGCGTCAAGGAGGTCGACATCGTCGTCGTCGGAGAATCGCGCATCGTCTCGCCCGCCGGCAAGAGATTCACCGAGTGGG
CCAAACGGCATCCGCCGTTCCCGGATTTCGAGCGCCCGACGCAGCCGCCGCTGGATGACGAAGCCATCTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References